Yes, with one important distinction. The kit is fully compatible with in-gel digestion workflows (trypsin, pepsin) because PEG — the precipitation reagent — does not migrate into the gel and does not interfere with MS analysis. For in-solution digestion workflows, PEG can cause ion suppression and background signals. We recommend consulting with your proteomics facility or contacting our technical team before proceeding with in-solution digestion. For EV proteomics using precipitation-based methods, we also recommend reviewing our application note on EV precipitation vs SEC for proteomics workflows.