Targeted Protein Degradation

Quickly knock-down protein activity using Piranha Targeted Protein Degradation System - robust, targeted protein degradation.

While studying protein function in vivo often involves knocking down expression using siRNA or knocking out the gene via CRISPR/Cas9, these approaches are indirect and often imperfect. siRNA can reduce or eliminate protein expression, but if the protein turn-over rate is slow then it can take days to see a reduction in function. Simply knocking out the gene coding for the protein-of-interest limits the type of studies you can do and is incompatible with essential genes. To give researchers another faster option, SBI developed the Piranha Targeted Protein Degradation System.

Targeted Protein Degradation Systems


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