pCDH-CMV-MCS2 Cloning and Expression Lentivector
With the strong CMV promoter upstream of an MCS, the pCDH-CMV-MCS2 lentivector is a great choice for stable gene expression when you don’t need a marker
- Multiple promoter options
- Multiple marker options—Puro, Neo, Hygro, GFP, or RFP
- Coordinated co-expression via T2A or IRES
- Single promoter, dual promoter, and bidirectional promoter formats
- High expression in most hematopoietic, embryonic, and stem cells via the MSCV CpG-deficient promoter
Products
Catalog Number | Description | Size | Price | Quantity | Add to Cart | |||
---|---|---|---|---|---|---|---|---|
CD501A-1 | pCDH-CMV-MCS2 cDNA Single Promoter Cloning and Expression Lentivector | 10 µg | $501 |
|
Overview
Overview
Get robust, stable expression of your gene-of-interest in dividing and quiescent cells Well-regarded in the industry for high, reliable gene expression, SBI’s lentiviral vectors come in a variety of formats that support a wide range of applications. The pCDH-CMV-MCS2 Cloning and Expression Lentivector is a great, streamlined lentivector for when you don’t need a marker or reporter (note that we offer this vector with a slightly different MCS for even greater flexibility—pCDH-CMV-MCS, Cat#. CD500B-1) With over thirty HIV-based lentivector options for gene expression, SBI’s family of pCDH Cloning and Expression Lentivectors provide the right lentivector for almost any gene expression project:- Multiple promoter options
- Multiple marker options—Puro, Neo, Hygro, GFP, or RFP
- Coordinated co-expression via T2A or IRES
- Single promoter, dual promoter, and bidirectional promoter formats
- High expression in most hematopoietic, embryonic, and stem cells via the MSCV CpG-deficient promoter
Promoter | Expression Level | Application |
---|---|---|
CMV | High | Commonly used in most cell lines (HeLa, HEK293, HT1080, etc.) |
MSCV | High | Hematopoietic and stem cells |
EF1α | Medium | Most cell types including primary cells and stem cells |
PGK | Medium | Most cell types including primary cells and stem cells |
UbC | Low | Most cell types including primary cells and stem cells |
How It Works
Supporting Data
FAQs
Resources
Related Products
Citations
-
Ge, LP, et al. (2024) ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer. Cell research. 2024; 34(1):58-75. PM ID: 38168642
-
Zhai, X, et al. (2024) LDLR is used as a cell entry receptor by multiple alphaviruses. Nature communications. 2024; 15(1):622. PM ID: 38245515
-
Sharma, P, et al. (2024) Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners. Nature communications. 2024; 15(1):473. PM ID: 38212624
-
Zhu, Q, et al. (2024) Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells. Nature communications. 2024; 15(1):40. PM ID: 38167292
-
Chen, SY, et al. (2024) Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression. Cancer letters. 2024;:216672. PM ID: 38280476
-
Shi, T, et al. (2024) Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide. Cell death & disease. 2024; 15(1):6. PM ID: 38177123
-
Rivera, M, et al. (2024) Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing. Cell reports. 2024; 43(2):113704. PM ID: 38265938
-
He, J, et al. (2024) Exosome-specific loading Sox10 for the treatment of Cuprizone-induced demyelinating model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024; 171:116128. PM ID: 38218078
-
Xiao, G, et al. (2024) Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition. Journal of translational medicine. 2024; 22(1):99. PM ID: 38268032
-
Wang, Q, et al. (2024) The pleiotropic enhancer enh9 promotes cell proliferation and migration in non-small cell lung cancer via ERMP1 and PD-L1. Biochimica et biophysica acta. Molecular basis of disease. 2024; 1870(3):167015. PM ID: 38182069
-
Samer, C, et al. (2024) Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection. iScience. 2024; 27(2):108801. PM ID: 38303725
-
Shen, Z, et al. (2024) Intrahepatic homeobox protein MSX-1 is a novel host restriction factor of hepatitis B virus. Journal of virology. 2024;:e0134523. PM ID: 38226815
-
Wu, H, et al. (2024) METTL14/miR-29c-3p axis drives aerobic glycolysis to promote triple-negative breast cancer progression though TRIM9-mediated PKM2 ubiquitination. Journal of cellular and molecular medicine. 2024;. PM ID: 38263865
-
Gong, Y, et al. (2024) Transcriptome sequencing analysis reveals miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/KRAS axis. Cellular signalling. 2024;:111068. PM ID: 38286198
-
Hong, J, et al. (2024) All-in-one IQ toggle switches with high versatilities for fine tuning of transgene expression in mammalian cells and tissues. Molecular Therapy - Methods & Clinical Development. 2024;:101202. Link: Molecular Therapy - Methods & Clinical Development
-
Li, J, et al. (2024) ECM1-associated miR-1260b promotes osteogenic differentiation by targeting GDI1. Acta histochemica. 2024; 126(1):152133. PM ID: 38266317
-
Yang, W, et al. (2024) Protein SUMOylation promotes cAMP-independent EPAC1 activation. bioRxiv : the preprint server for biology. 2024;. PM ID: 38260470
-
Wu, Z, et al. (2024) Targeting CaMKII-δ/DHCR24 axis is a novel strategy against acute myeloid leukemia. Research Square. 2024;. Link: Research Square
-
Bataclan, M, et al. (2024) Crosstalk between the RNA-binding proteins Regnase-1 and -3 shapes mast cell survival and cytokine expression. bioRxiv. 2024;. Link: bioRxiv
-
Giblin, A, et al. (2024) Neuronal polyunsaturated fatty acids are protective in FTD/ALS. bioRxiv. 2024;. Link: bioRxiv
- See More
pCDH-CMV-MCS2 Cloning and Expression Lentivector
$501.00
Products
Catalog Number | Description | Size | Price | Quantity | Add to Cart | |||
---|---|---|---|---|---|---|---|---|
CD501A-1 | pCDH-CMV-MCS2 cDNA Single Promoter Cloning and Expression Lentivector | 10 µg | $501 |
|
Overview
Overview
Get robust, stable expression of your gene-of-interest in dividing and quiescent cells Well-regarded in the industry for high, reliable gene expression, SBI’s lentiviral vectors come in a variety of formats that support a wide range of applications. The pCDH-CMV-MCS2 Cloning and Expression Lentivector is a great, streamlined lentivector for when you don’t need a marker or reporter (note that we offer this vector with a slightly different MCS for even greater flexibility—pCDH-CMV-MCS, Cat#. CD500B-1) With over thirty HIV-based lentivector options for gene expression, SBI’s family of pCDH Cloning and Expression Lentivectors provide the right lentivector for almost any gene expression project:- Multiple promoter options
- Multiple marker options—Puro, Neo, Hygro, GFP, or RFP
- Coordinated co-expression via T2A or IRES
- Single promoter, dual promoter, and bidirectional promoter formats
- High expression in most hematopoietic, embryonic, and stem cells via the MSCV CpG-deficient promoter
Promoter | Expression Level | Application |
---|---|---|
CMV | High | Commonly used in most cell lines (HeLa, HEK293, HT1080, etc.) |
MSCV | High | Hematopoietic and stem cells |
EF1α | Medium | Most cell types including primary cells and stem cells |
PGK | Medium | Most cell types including primary cells and stem cells |
UbC | Low | Most cell types including primary cells and stem cells |
How It Works
Supporting Data
FAQs
Citations
-
Ge, LP, et al. (2024) ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer. Cell research. 2024; 34(1):58-75. PM ID: 38168642
-
Zhai, X, et al. (2024) LDLR is used as a cell entry receptor by multiple alphaviruses. Nature communications. 2024; 15(1):622. PM ID: 38245515
-
Sharma, P, et al. (2024) Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners. Nature communications. 2024; 15(1):473. PM ID: 38212624
-
Zhu, Q, et al. (2024) Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells. Nature communications. 2024; 15(1):40. PM ID: 38167292
-
Chen, SY, et al. (2024) Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression. Cancer letters. 2024;:216672. PM ID: 38280476
-
Shi, T, et al. (2024) Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide. Cell death & disease. 2024; 15(1):6. PM ID: 38177123
-
Rivera, M, et al. (2024) Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing. Cell reports. 2024; 43(2):113704. PM ID: 38265938
-
He, J, et al. (2024) Exosome-specific loading Sox10 for the treatment of Cuprizone-induced demyelinating model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024; 171:116128. PM ID: 38218078
-
Xiao, G, et al. (2024) Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition. Journal of translational medicine. 2024; 22(1):99. PM ID: 38268032
-
Wang, Q, et al. (2024) The pleiotropic enhancer enh9 promotes cell proliferation and migration in non-small cell lung cancer via ERMP1 and PD-L1. Biochimica et biophysica acta. Molecular basis of disease. 2024; 1870(3):167015. PM ID: 38182069
-
Samer, C, et al. (2024) Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection. iScience. 2024; 27(2):108801. PM ID: 38303725
-
Shen, Z, et al. (2024) Intrahepatic homeobox protein MSX-1 is a novel host restriction factor of hepatitis B virus. Journal of virology. 2024;:e0134523. PM ID: 38226815
-
Wu, H, et al. (2024) METTL14/miR-29c-3p axis drives aerobic glycolysis to promote triple-negative breast cancer progression though TRIM9-mediated PKM2 ubiquitination. Journal of cellular and molecular medicine. 2024;. PM ID: 38263865
-
Gong, Y, et al. (2024) Transcriptome sequencing analysis reveals miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/KRAS axis. Cellular signalling. 2024;:111068. PM ID: 38286198
-
Hong, J, et al. (2024) All-in-one IQ toggle switches with high versatilities for fine tuning of transgene expression in mammalian cells and tissues. Molecular Therapy - Methods & Clinical Development. 2024;:101202. Link: Molecular Therapy - Methods & Clinical Development
-
Li, J, et al. (2024) ECM1-associated miR-1260b promotes osteogenic differentiation by targeting GDI1. Acta histochemica. 2024; 126(1):152133. PM ID: 38266317
-
Yang, W, et al. (2024) Protein SUMOylation promotes cAMP-independent EPAC1 activation. bioRxiv : the preprint server for biology. 2024;. PM ID: 38260470
-
Wu, Z, et al. (2024) Targeting CaMKII-δ/DHCR24 axis is a novel strategy against acute myeloid leukemia. Research Square. 2024;. Link: Research Square
-
Bataclan, M, et al. (2024) Crosstalk between the RNA-binding proteins Regnase-1 and -3 shapes mast cell survival and cytokine expression. bioRxiv. 2024;. Link: bioRxiv
-
Giblin, A, et al. (2024) Neuronal polyunsaturated fatty acids are protective in FTD/ALS. bioRxiv. 2024;. Link: bioRxiv
- See More