ExoQuick-TC

Fast, scalable exosome isolation from tissue culture media
  • Saves time and labor
  • Is easily scalable
  • Conserves precious sample
  • Delivers high yields of functional, high quality exosomes
  • Can be used to isolate exosomes for a wide range of downstream applications, including
    Biomarker studies
    Exosomal miRNA profiling
    Exosomal proteomics
    Exosomal lipidomics/metabolomics
    Functional studies, such as in cell-to-cell signaling
    Basic biology, such as role in tumorigenesis

Products

Catalog Number Description Size Price Quantity Add to Cart
EXOTC10A-1 ExoQuick-TC 10 mL $354
- +
EXOTC50A-1 ExoQuick-TC 50 mL $1189
- +

Overview

Overview

A better way to isolate exosomes

"We therefore pursued the ExoQuick® method for further study, as these samples required much less sample input, a key benefit when working with clinical samples and mouse models1."

Need exosomes? SBI's ExoQuick-TC enables high-throughput, quantitative isolation of exosomes from low volumes (as little as 1 ml) of tissue culture media and certain biofluids (saliva, urine, follicular fluid, and breast milk). Note, to isolate exosomes from serum, plasma, or ascites fluid, use the original ExoQuick formulation (EXOQ5A-1 or EXOQ20A-1). Compatible with a wide variety of downstream applications, ExoQuick-TC is an effective and proven alternative to ultracentrifugation1-3.

ExoQuick-TC’s fast, ultracentrifugation-free method:

  • Saves time and labor
  • Is easily scalable
  • Conserves precious sample
  • Delivers high yields of functional, high quality exosomes
  • Can be used to isolate exosomes for a wide range of downstream applications, including
    • Biomarker studies
    • Exosomal miRNA profiling
    • Exosomal proteomics
    • Exosomal lipidomics/metabolomics
    • Functional studies, such as in cell-to-cell signaling
    • Basic biology, such as role in tumorigenesis

ExoQuick-TC is a proprietary polymer that gently precipitates exosomes. First, pre-clear your samples of cells and cellular debris, and then simply add the appropriate amount of ExoQuick-TC to your cleared biofluid, refrigerate, and centrifuge (see the product manual for protocol details). Your exosomes will be in the pellet, ready for resuspension in an appropriate solution.

BiofluidSample volumeExoQuick-TC Volume
Tissue culture media, urine, cerebrospinal fluid (CSF), etc.5 mL1 mL

In electron microscopy studies, exosomes isolated with ExoQuick-TC appear similar to exosomes isolated using ultracentrifugation1-2, and these exosomes are also active in numerous functional assays1-3.

Exosomes isolated with ExoQuick-TC can be used for all types of protein profiling and protein characterization studies, such as mass spectrometry, Western blotting, ELISA, and more. Higher protein yields are achieved by ExoQuick purification than by chromatography, DynaBeads, or ultracentrifugation.

Exosomes isolated with ExoQuick-TC also provide excellent samples for studying exosome-associated nucleic acids such as microRNAs, siRNAs, and even mRNA. Quantitative analytical techniques such as qPCR, microarray studies, and next-generation sequencing are all compatible with nucleic acids isolated from ExoQuick-TC-purified exosomes.

Backed by a growing number of publications, ExoQuick-TC is often the best option for researchers working with low sample volumes, such as clinical research samples or small animal models.

ExoQuick-TC exosome isolation methods are patented technologies4.

Choose the right ExoQuick for your application:

ApplicationProductCatalog #
Purest EV isolationExoQuick ULTRA and
ExoQuick-TC ULTRA
EQULTRA-20A-1
EQULTRA-20TC-1
General purpose EV isolationExoQuick and
ExoQuick-TC
EXOQ20A-1
EXOTC50A-1
EV isolation for pre-clinical/in vivo studiesExoQuick-CGEXOCG50A-1
EV isolation that removes contaminating lipoprotein particles from plasma or serumExoQuick-LPEXOLP5A-1
EV isolation that includes a de-fibrinating plasma step prior to isolationExoQuick Plasma Prep with ThrombinEXOQ5TM-1

REFERENCES

  1. Chugh PE, et al. Systemically Circulating Viral and Tumor-Derived MicroRNAs in KSHV-Associated Malignancies. PLoS Pathog. 2013. 9(7): e1003484. PMCID: PMC3715412.
  1. Umezu T, et al. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene. 2013 May 30. 32(22):2747-55. PMID: 22797057.
  1. Sohel MM, et al. Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence. PLoS One. 2013 Nov 4. 8(11):e78505. PMCID: PMC3817212.
  1. Antes T, et al. Methods for Microvesicle Isolation and Selective Removal. Patent No.: US 9,005,888 B2.

How It Works

How It Works

High-throughput, quantitative exosome recovery

ExoQuick-TC can be used to purify exosomes from a wide variety of tissue culture media4, and from certain biofluids such as saliva1, urine2, follicular fluid3, and breast milk5. With a simple workflow involving minimal hands-on time and low input sample volume requirements, ExoQuick-TC is an excellent option for researchers who need to purify multiple exosome samples.

To isolate exosomes from tissue culture media, simply:

  • Add an appropriate volume of ExoQuick-TC
  • Incubate overnight at 4°C
  • Isolate exosomes with a 30-minute low-speed spin (1500g).

Isolated exosomes can be found in the pellet and resuspended in an appropriate solution.

A quick and easy exosome isolation workflow

You can verify the presence of exosomes with a number of different methods, including Western blotting for general exosome markers (CD63, CD9, CD81, and HSP70), NanoSight analysis, or EM (learn about different ways to detect exosomes and more in our Exosome Basics Guide).

The Bottom Line
With ExoQuick-TC, you can obtain high-quality exosomes from tissue culture media and certain biofluids using a protocol that can easily be performed on multiple samples and requires very low volumes of input sample.

REFERENCES

  1. Yang J, et al. Detection of Tumor Cell-Specific mRNA and Protein in Exosome-Like Microvesicles from Blood and Saliva. PLoS ONE. 2014. 9(11): e110641. PMCID: PMC 4232306.
  1. Alvarez ML. Isolation of urinary exosomes for RNA biomarker discovery using a simple, fast, and highly scalable method. Methods Mol Biol. 2014. 1182:145-70. PMID: 25055908.
  1. Sohel MM, et al. Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence. PLoS One. 2013 Nov 4. 8(11):e78505. PMCID: PMC3817212.
  1. Zhu L, et al. Novel method for extracting exosomes of hepatocellular carcinoma cells. World J Gastroenterol. 2014 June 7. 20(21): 6651-6657. PMCID: PMC4047354.
  1. Gu Y, et al. Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes. PLoS ONE. 2012. 7(8): e43691. PMCID: PMC3427246.

 

Supporting Data

Supporting Data

Characterizing ExoQuick-TC exosomes with NanoSight

Exosomes purified with ExoQuick-TC from tissue culture media show the expected particle size distribution and high concentration yields when analyzed using NanoSight’s Nanoparticle Tracking Analysis (NTA, Figure 1).

ExoQuick-TC delivers high yields of particles consistent in size with exosomes

Figure 3.Exosome size distribution and yields from tissue culture media. Cells from a human HT1080 lung sarcoma cell line were cultured in conditioned media (serum-free) for 72 hours. 10 mL of media was combined with 2 mL ExoQuick-TC, incubated overnight at 4°C, and centrifuged at 1500g for 30 minutes to isolate exosomes. The exosome pellet was resuspended in 1 mL PBS, diluted 1:40, and visualized on the NanoSight LM10 instrument. The analysis shows that ExoQuick-TC recovered 133 nm exosomes at a concentration of 1.74 x 109 particles/mL.

FAQs

ExoQuick-TC is a fast and scalable method for isolating exosomes from tissue culture media and certain non-viscous biofluids (saliva, urine, follicular fluid, and breast milk). It is a proprietary polymer that gently precipitates exosomes, providing high yields of functional, high-quality exosomes that are suitable for a wide range of downstream applications.
ExoQuick-TC saves time and labor, conserves precious sample, delivers high yields of functional, high-quality exosomes, and is easily scalable. It can be used for a wide range of downstream applications, including biomarker studies, exosomal miRNA profiling, exosomal proteomics, exosomal lipidomics/metabolomics, functional studies, and basic biology.
ExoQuick-TC can be used to purify exosomes from a wide variety of tissue culture media, and from certain biofluids such as saliva, urine, follicular fluid, and breast milk.
ExoQuick-TC-isolated exosomes can be used for a wide range of downstream applications, including biomarker studies, exosomal miRNA profiling, exosomal proteomics, exosomal lipidomics/metabolomics, functional studies (such as in cell-to-cell signaling), and basic biology (such as role in tumorigenesis).
Yes, ExoQuick-TC is an excellent option for researchers working with low sample volumes, such as clinical research samples or small animal models.
To isolate exosomes from tissue culture media, simply add an appropriate volume of ExoQuick-TC, incubate overnight at 4°C, and isolate exosomes with a 30-minute low-speed spin (1500g). Isolated exosomes can be found in the pellet and resuspended in an appropriate solution.
You can verify the presence of exosomes with a number of different methods, including ELISA/Western blotting for general exosome markers (CD63, CD9, CD81, and HSP70) or EXORAY panel, NanoSight analysis, or electron microscopy.

Resources

Citations

  • Wu, TY, et al. (2024) Mucin-mediated mucosal retention via end-terminal modified Pluronic F127-based hydrogel to increase drug accumulation in the lungs. Biomaterials advances. 2024; 156:213722. PM ID: 38101076
  • Arai, Y, et al. (2023) Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists. iScience. 2023; 26(1):105742. PM ID: 36507221
  • Robinson, H, et al. (2023) Extracellular vesicles for precision medicine in prostate cancer – Is it ready for clinical translation?. Seminars in cancer biology. 2023; 89:18-29. PM ID: 36681206
  • Song, X, Xu, L & Zhang, W. (2023) Biomimetic synthesis and optimization of extracellular vesicles for bone regeneration. Journal of controlled release : official journal of the Controlled Release Society. 2023;. PM ID: 36706840
  • Nguyen Cao, TG, et al. (2023) Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy. Journal of controlled release : official journal of the Controlled Release Society. 2023; 354:651-663. PM ID: 36682729
  • Zhang, S, et al. (2023) Calpain-2 Facilitates Autophagic/Lysosomal Defects and Apoptosis in ARPE-19 Cells and Rats Induced by Exosomes from RPE Cells under NaIO3 Stimulation. Oxidative medicine and cellular longevity. 2023; 2023:3310621. PM ID: 36703913
  • Hu, R, et al. (2023) LINC00963 promotes the malignancy and metastasis of lung adenocarcinoma by stabilizing Zeb1 and exosomes-induced M2 macrophage polarization. Molecular medicine (Cambridge, Mass.). 2023; 29(1):1. PM ID: 36604626
  • Moirangthem, A, et al. (2023) Extracellular vesicle‑mediated miR‑126‑3p transfer contributes to inter‑cellular communication in the liver tumor microenvironment. International journal of oncology. 2023; 62(2). PM ID: 36660950
  • Xiong, H, et al. (2023) circ_rac GTPase-Activating Protein 1 Facilitates Stemness and Metastasis of Non-Small Cell Lung Cancer via Polypyrimidine Tract-Binding Protein 1 Recruitment to Promote Sirtuin-3-Mediated Replication Timing Regulatory Factor 1 Deacetylation. Laboratory Investigation. 2023; 103(1):100010. Link: Laboratory Investigation
  • Khalil, S & Kanapathipillai, M. (2023) Exosome-Coated tPA/Catalase Nanoformulation for Thrombolytic Therapy. Bioengineering. 2023; 10(2):177. Link: Bioengineering
  • Wang, H & zhang, x. (2023) Effect of Exosomes from Different Cell Sources on Differentiation of Bone Marrow Mesenchymal Stem Cells into Schwann Cells. SSRN Electronic Journal. 2023;. Link: SSRN Electronic Journal
  • Zhang, W, et al. (2023) Exosomal circEZH2_005, an intestinal injury biomarker, alleviates intestinal ischemia/reperfusion injury by mediating hnRNPA1/Gprc5a signaling. Research Square. 2023;. Link: Research Square
  • Ma, Z, et al. (2023) Exosomal PGE2 from M2 macrophage inhibits neutrophil recruitment and NET formation through lipid mediator class switching in sepsis. Research Square. 2023;. Link: Research Square
  • Pan, B, et al. (2023) Macrophages-derived exosomes modulates wear particle-induced osteolysis via miR-3470b targeting TAB3/NF-κB signaling. Bioactive Materials. 2023; 26:181-193. Link: Bioactive Materials
  • Davies, OG. (2023) Extracellular Vesicles: From Bone Development to Regenerative Orthopaedics. Molecular therapy : the journal of the American Society of Gene Therapy. 2023;. PM ID: 36869588
  • Xie, J, et al. (2023) Targeted therapy for peri-prosthetic osteolysis using macrophage membrane-encapsulated human urine-derived stem cell extracellular vesicles. Acta biomaterialia. 2023;. PM ID: 36773884
  • Jiao, W, et al. (2023) Induced pluripotent stem cell-derived extracellular vesicles overexpressing SFPQ protect retinal Müller cells against hypoxia-induced injury. Cell biology and toxicology. 2023;. PM ID: 36790503
  • Kotelevets, L & Chastre, E. (2023) Extracellular Vesicles in Colorectal Cancer: From Tumor Growth and Metastasis to Biomarkers and Nanomedications. Cancers. 2023; 15(4). PM ID: 36831450
  • Zhang, Y, et al. (2023) CCR7 Mediates Dendritic-Cell-Derived Exosome Migration and Improves Cardiac Function after Myocardial Infarction. Pharmaceutics. 2023; 15(2). PM ID: 36839783
  • Gong, Y, et al. (2023) Exosomes derived from human adipose-derived stem cells alleviate hepatic ischemia-reperfusion (I/R) injury through the miR-183/ALOX5 axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023; 37(3):e22782. PM ID: 36786721

Products

Catalog Number Description Size Price Quantity Add to Cart
EXOTC10A-1 ExoQuick-TC 10 mL $354
- +
EXOTC50A-1 ExoQuick-TC 50 mL $1189
- +

Overview

Overview

A better way to isolate exosomes

"We therefore pursued the ExoQuick® method for further study, as these samples required much less sample input, a key benefit when working with clinical samples and mouse models1."

Need exosomes? SBI's ExoQuick-TC enables high-throughput, quantitative isolation of exosomes from low volumes (as little as 1 ml) of tissue culture media and certain biofluids (saliva, urine, follicular fluid, and breast milk). Note, to isolate exosomes from serum, plasma, or ascites fluid, use the original ExoQuick formulation (EXOQ5A-1 or EXOQ20A-1). Compatible with a wide variety of downstream applications, ExoQuick-TC is an effective and proven alternative to ultracentrifugation1-3.

ExoQuick-TC’s fast, ultracentrifugation-free method:

  • Saves time and labor
  • Is easily scalable
  • Conserves precious sample
  • Delivers high yields of functional, high quality exosomes
  • Can be used to isolate exosomes for a wide range of downstream applications, including
    • Biomarker studies
    • Exosomal miRNA profiling
    • Exosomal proteomics
    • Exosomal lipidomics/metabolomics
    • Functional studies, such as in cell-to-cell signaling
    • Basic biology, such as role in tumorigenesis

ExoQuick-TC is a proprietary polymer that gently precipitates exosomes. First, pre-clear your samples of cells and cellular debris, and then simply add the appropriate amount of ExoQuick-TC to your cleared biofluid, refrigerate, and centrifuge (see the product manual for protocol details). Your exosomes will be in the pellet, ready for resuspension in an appropriate solution.

BiofluidSample volumeExoQuick-TC Volume
Tissue culture media, urine, cerebrospinal fluid (CSF), etc.5 mL1 mL

In electron microscopy studies, exosomes isolated with ExoQuick-TC appear similar to exosomes isolated using ultracentrifugation1-2, and these exosomes are also active in numerous functional assays1-3.

Exosomes isolated with ExoQuick-TC can be used for all types of protein profiling and protein characterization studies, such as mass spectrometry, Western blotting, ELISA, and more. Higher protein yields are achieved by ExoQuick purification than by chromatography, DynaBeads, or ultracentrifugation.

Exosomes isolated with ExoQuick-TC also provide excellent samples for studying exosome-associated nucleic acids such as microRNAs, siRNAs, and even mRNA. Quantitative analytical techniques such as qPCR, microarray studies, and next-generation sequencing are all compatible with nucleic acids isolated from ExoQuick-TC-purified exosomes.

Backed by a growing number of publications, ExoQuick-TC is often the best option for researchers working with low sample volumes, such as clinical research samples or small animal models.

ExoQuick-TC exosome isolation methods are patented technologies4.

Choose the right ExoQuick for your application:

ApplicationProductCatalog #
Purest EV isolationExoQuick ULTRA and
ExoQuick-TC ULTRA
EQULTRA-20A-1
EQULTRA-20TC-1
General purpose EV isolationExoQuick and
ExoQuick-TC
EXOQ20A-1
EXOTC50A-1
EV isolation for pre-clinical/in vivo studiesExoQuick-CGEXOCG50A-1
EV isolation that removes contaminating lipoprotein particles from plasma or serumExoQuick-LPEXOLP5A-1
EV isolation that includes a de-fibrinating plasma step prior to isolationExoQuick Plasma Prep with ThrombinEXOQ5TM-1

REFERENCES

  1. Chugh PE, et al. Systemically Circulating Viral and Tumor-Derived MicroRNAs in KSHV-Associated Malignancies. PLoS Pathog. 2013. 9(7): e1003484. PMCID: PMC3715412.
  1. Umezu T, et al. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene. 2013 May 30. 32(22):2747-55. PMID: 22797057.
  1. Sohel MM, et al. Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence. PLoS One. 2013 Nov 4. 8(11):e78505. PMCID: PMC3817212.
  1. Antes T, et al. Methods for Microvesicle Isolation and Selective Removal. Patent No.: US 9,005,888 B2.

How It Works

How It Works

High-throughput, quantitative exosome recovery

ExoQuick-TC can be used to purify exosomes from a wide variety of tissue culture media4, and from certain biofluids such as saliva1, urine2, follicular fluid3, and breast milk5. With a simple workflow involving minimal hands-on time and low input sample volume requirements, ExoQuick-TC is an excellent option for researchers who need to purify multiple exosome samples.

To isolate exosomes from tissue culture media, simply:

  • Add an appropriate volume of ExoQuick-TC
  • Incubate overnight at 4°C
  • Isolate exosomes with a 30-minute low-speed spin (1500g).

Isolated exosomes can be found in the pellet and resuspended in an appropriate solution.

A quick and easy exosome isolation workflow

You can verify the presence of exosomes with a number of different methods, including Western blotting for general exosome markers (CD63, CD9, CD81, and HSP70), NanoSight analysis, or EM (learn about different ways to detect exosomes and more in our Exosome Basics Guide).

The Bottom Line
With ExoQuick-TC, you can obtain high-quality exosomes from tissue culture media and certain biofluids using a protocol that can easily be performed on multiple samples and requires very low volumes of input sample.

REFERENCES

  1. Yang J, et al. Detection of Tumor Cell-Specific mRNA and Protein in Exosome-Like Microvesicles from Blood and Saliva. PLoS ONE. 2014. 9(11): e110641. PMCID: PMC 4232306.
  1. Alvarez ML. Isolation of urinary exosomes for RNA biomarker discovery using a simple, fast, and highly scalable method. Methods Mol Biol. 2014. 1182:145-70. PMID: 25055908.
  1. Sohel MM, et al. Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence. PLoS One. 2013 Nov 4. 8(11):e78505. PMCID: PMC3817212.
  1. Zhu L, et al. Novel method for extracting exosomes of hepatocellular carcinoma cells. World J Gastroenterol. 2014 June 7. 20(21): 6651-6657. PMCID: PMC4047354.
  1. Gu Y, et al. Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes. PLoS ONE. 2012. 7(8): e43691. PMCID: PMC3427246.

 

Supporting Data

Supporting Data

Characterizing ExoQuick-TC exosomes with NanoSight

Exosomes purified with ExoQuick-TC from tissue culture media show the expected particle size distribution and high concentration yields when analyzed using NanoSight’s Nanoparticle Tracking Analysis (NTA, Figure 1).

ExoQuick-TC delivers high yields of particles consistent in size with exosomes

Figure 3.Exosome size distribution and yields from tissue culture media. Cells from a human HT1080 lung sarcoma cell line were cultured in conditioned media (serum-free) for 72 hours. 10 mL of media was combined with 2 mL ExoQuick-TC, incubated overnight at 4°C, and centrifuged at 1500g for 30 minutes to isolate exosomes. The exosome pellet was resuspended in 1 mL PBS, diluted 1:40, and visualized on the NanoSight LM10 instrument. The analysis shows that ExoQuick-TC recovered 133 nm exosomes at a concentration of 1.74 x 109 particles/mL.

FAQs

ExoQuick-TC is a fast and scalable method for isolating exosomes from tissue culture media and certain non-viscous biofluids (saliva, urine, follicular fluid, and breast milk). It is a proprietary polymer that gently precipitates exosomes, providing high yields of functional, high-quality exosomes that are suitable for a wide range of downstream applications.
ExoQuick-TC saves time and labor, conserves precious sample, delivers high yields of functional, high-quality exosomes, and is easily scalable. It can be used for a wide range of downstream applications, including biomarker studies, exosomal miRNA profiling, exosomal proteomics, exosomal lipidomics/metabolomics, functional studies, and basic biology.
ExoQuick-TC can be used to purify exosomes from a wide variety of tissue culture media, and from certain biofluids such as saliva, urine, follicular fluid, and breast milk.
ExoQuick-TC-isolated exosomes can be used for a wide range of downstream applications, including biomarker studies, exosomal miRNA profiling, exosomal proteomics, exosomal lipidomics/metabolomics, functional studies (such as in cell-to-cell signaling), and basic biology (such as role in tumorigenesis).
Yes, ExoQuick-TC is an excellent option for researchers working with low sample volumes, such as clinical research samples or small animal models.
To isolate exosomes from tissue culture media, simply add an appropriate volume of ExoQuick-TC, incubate overnight at 4°C, and isolate exosomes with a 30-minute low-speed spin (1500g). Isolated exosomes can be found in the pellet and resuspended in an appropriate solution.
You can verify the presence of exosomes with a number of different methods, including ELISA/Western blotting for general exosome markers (CD63, CD9, CD81, and HSP70) or EXORAY panel, NanoSight analysis, or electron microscopy.

Citations

  • Wu, TY, et al. (2024) Mucin-mediated mucosal retention via end-terminal modified Pluronic F127-based hydrogel to increase drug accumulation in the lungs. Biomaterials advances. 2024; 156:213722. PM ID: 38101076
  • Arai, Y, et al. (2023) Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists. iScience. 2023; 26(1):105742. PM ID: 36507221
  • Robinson, H, et al. (2023) Extracellular vesicles for precision medicine in prostate cancer – Is it ready for clinical translation?. Seminars in cancer biology. 2023; 89:18-29. PM ID: 36681206
  • Song, X, Xu, L & Zhang, W. (2023) Biomimetic synthesis and optimization of extracellular vesicles for bone regeneration. Journal of controlled release : official journal of the Controlled Release Society. 2023;. PM ID: 36706840
  • Nguyen Cao, TG, et al. (2023) Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy. Journal of controlled release : official journal of the Controlled Release Society. 2023; 354:651-663. PM ID: 36682729
  • Zhang, S, et al. (2023) Calpain-2 Facilitates Autophagic/Lysosomal Defects and Apoptosis in ARPE-19 Cells and Rats Induced by Exosomes from RPE Cells under NaIO3 Stimulation. Oxidative medicine and cellular longevity. 2023; 2023:3310621. PM ID: 36703913
  • Hu, R, et al. (2023) LINC00963 promotes the malignancy and metastasis of lung adenocarcinoma by stabilizing Zeb1 and exosomes-induced M2 macrophage polarization. Molecular medicine (Cambridge, Mass.). 2023; 29(1):1. PM ID: 36604626
  • Moirangthem, A, et al. (2023) Extracellular vesicle‑mediated miR‑126‑3p transfer contributes to inter‑cellular communication in the liver tumor microenvironment. International journal of oncology. 2023; 62(2). PM ID: 36660950
  • Xiong, H, et al. (2023) circ_rac GTPase-Activating Protein 1 Facilitates Stemness and Metastasis of Non-Small Cell Lung Cancer via Polypyrimidine Tract-Binding Protein 1 Recruitment to Promote Sirtuin-3-Mediated Replication Timing Regulatory Factor 1 Deacetylation. Laboratory Investigation. 2023; 103(1):100010. Link: Laboratory Investigation
  • Khalil, S & Kanapathipillai, M. (2023) Exosome-Coated tPA/Catalase Nanoformulation for Thrombolytic Therapy. Bioengineering. 2023; 10(2):177. Link: Bioengineering
  • Wang, H & zhang, x. (2023) Effect of Exosomes from Different Cell Sources on Differentiation of Bone Marrow Mesenchymal Stem Cells into Schwann Cells. SSRN Electronic Journal. 2023;. Link: SSRN Electronic Journal
  • Zhang, W, et al. (2023) Exosomal circEZH2_005, an intestinal injury biomarker, alleviates intestinal ischemia/reperfusion injury by mediating hnRNPA1/Gprc5a signaling. Research Square. 2023;. Link: Research Square
  • Ma, Z, et al. (2023) Exosomal PGE2 from M2 macrophage inhibits neutrophil recruitment and NET formation through lipid mediator class switching in sepsis. Research Square. 2023;. Link: Research Square
  • Pan, B, et al. (2023) Macrophages-derived exosomes modulates wear particle-induced osteolysis via miR-3470b targeting TAB3/NF-κB signaling. Bioactive Materials. 2023; 26:181-193. Link: Bioactive Materials
  • Davies, OG. (2023) Extracellular Vesicles: From Bone Development to Regenerative Orthopaedics. Molecular therapy : the journal of the American Society of Gene Therapy. 2023;. PM ID: 36869588
  • Xie, J, et al. (2023) Targeted therapy for peri-prosthetic osteolysis using macrophage membrane-encapsulated human urine-derived stem cell extracellular vesicles. Acta biomaterialia. 2023;. PM ID: 36773884
  • Jiao, W, et al. (2023) Induced pluripotent stem cell-derived extracellular vesicles overexpressing SFPQ protect retinal Müller cells against hypoxia-induced injury. Cell biology and toxicology. 2023;. PM ID: 36790503
  • Kotelevets, L & Chastre, E. (2023) Extracellular Vesicles in Colorectal Cancer: From Tumor Growth and Metastasis to Biomarkers and Nanomedications. Cancers. 2023; 15(4). PM ID: 36831450
  • Zhang, Y, et al. (2023) CCR7 Mediates Dendritic-Cell-Derived Exosome Migration and Improves Cardiac Function after Myocardial Infarction. Pharmaceutics. 2023; 15(2). PM ID: 36839783
  • Gong, Y, et al. (2023) Exosomes derived from human adipose-derived stem cells alleviate hepatic ischemia-reperfusion (I/R) injury through the miR-183/ALOX5 axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023; 37(3):e22782. PM ID: 36786721