ExoQuick-TC

Fast, scalable exosome isolation from tissue culture media
  • Saves time and labor
  • Is easily scalable
  • Conserves precious sample
  • Delivers high yields of functional, high quality exosomes
  • Can be used to isolate exosomes for a wide range of downstream applications, including
    Biomarker studies
    Exosomal miRNA profiling
    Exosomal proteomics
    Exosomal lipidomics/metabolomics
    Functional studies, such as in cell-to-cell signaling
    Basic biology, such as role in tumorigenesis

Products

Catalog Number Description Size Price Quantity Add to Cart
EXOTC10A-1 ExoQuick-TC 10 mL $334
- +
EXOTC50A-1 ExoQuick-TC 50 mL $1124
- +

Overview

Overview

A better way to isolate exosomes

"We therefore pursued the ExoQuick® method for further study, as these samples required much less sample input, a key benefit when working with clinical samples and mouse models1."

Need exosomes? SBI's ExoQuick-TC enables high-throughput, quantitative isolation of exosomes from low volumes (as little as 1 ml) of tissue culture media and certain biofluids (saliva, urine, follicular fluid, and breast milk). Note, to isolate exosomes from serum, plasma, or ascites fluid, use the original ExoQuick formulation (EXOQ5A-1 or EXOQ20A-1). Compatible with a wide variety of downstream applications, ExoQuick-TC is an effective and proven alternative to ultracentrifugation1-3.

ExoQuick-TC’s fast, ultracentrifugation-free method:

  • Saves time and labor
  • Is easily scalable
  • Conserves precious sample
  • Delivers high yields of functional, high quality exosomes
  • Can be used to isolate exosomes for a wide range of downstream applications, including
    • Biomarker studies
    • Exosomal miRNA profiling
    • Exosomal proteomics
    • Exosomal lipidomics/metabolomics
    • Functional studies, such as in cell-to-cell signaling
    • Basic biology, such as role in tumorigenesis

ExoQuick-TC is a proprietary polymer that gently precipitates exosomes. First, pre-clear your samples of cells and cellular debris, and then simply add the appropriate amount of ExoQuick-TC to your cleared biofluid, refrigerate, and centrifuge (see the product manual for protocol details). Your exosomes will be in the pellet, ready for resuspension in an appropriate solution.

BiofluidSample volumeExoQuick-TC Volume
Tissue culture media, urine, cerebrospinal fluid (CSF), etc.5 mL1 mL

In electron microscopy studies, exosomes isolated with ExoQuick-TC appear similar to exosomes isolated using ultracentrifugation1-2, and these exosomes are also active in numerous functional assays1-3.

Exosomes isolated with ExoQuick-TC can be used for all types of protein profiling and protein characterization studies, such as mass spectrometry, Western blotting, ELISA, and more. Higher protein yields are achieved by ExoQuick purification than by chromatography, DynaBeads, or ultracentrifugation.

Exosomes isolated with ExoQuick-TC also provide excellent samples for studying exosome-associated nucleic acids such as microRNAs, siRNAs, and even mRNA. Quantitative analytical techniques such as qPCR, microarray studies, and next-generation sequencing are all compatible with nucleic acids isolated from ExoQuick-TC-purified exosomes.

Backed by a growing number of publications, ExoQuick-TC is often the best option for researchers working with low sample volumes, such as clinical research samples or small animal models.

ExoQuick-TC exosome isolation methods are patented technologies4.

Choose the right ExoQuick for your application:

ApplicationProductCatalog #
Purest EV isolationExoQuick ULTRA and
ExoQuick-TC ULTRA
EQULTRA-20A-1
EQULTRA-20TC-1
General purpose EV isolationExoQuick and
ExoQuick-TC
EXOQ20A-1
EXOTC50A-1
EV isolation for pre-clinical/in vivo studiesExoQuick-CGEXOCG50A-1
EV isolation that removes contaminating lipoprotein particles from plasma or serumExoQuick-LPEXOLP5A-1
EV isolation that includes a de-fibrinating plasma step prior to isolationExoQuick Plasma Prep with ThrombinEXOQ5TM-1

REFERENCES

  1. Chugh PE, et al. Systemically Circulating Viral and Tumor-Derived MicroRNAs in KSHV-Associated Malignancies. PLoS Pathog. 2013. 9(7): e1003484. PMCID: PMC3715412.
  1. Umezu T, et al. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene. 2013 May 30. 32(22):2747-55. PMID: 22797057.
  1. Sohel MM, et al. Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence. PLoS One. 2013 Nov 4. 8(11):e78505. PMCID: PMC3817212.
  1. Antes T, et al. Methods for Microvesicle Isolation and Selective Removal. Patent No.: US 9,005,888 B2.

How It Works

How It Works

High-throughput, quantitative exosome recovery

ExoQuick-TC can be used to purify exosomes from a wide variety of tissue culture media4, and from certain biofluids such as saliva1, urine2, follicular fluid3, and breast milk5. With a simple workflow involving minimal hands-on time and low input sample volume requirements, ExoQuick-TC is an excellent option for researchers who need to purify multiple exosome samples.

To isolate exosomes from tissue culture media, simply:

  • Add an appropriate volume of ExoQuick-TC
  • Incubate overnight at 4°C
  • Isolate exosomes with a 30-minute low-speed spin (1500g).

Isolated exosomes can be found in the pellet and resuspended in an appropriate solution.

A quick and easy exosome isolation workflow

You can verify the presence of exosomes with a number of different methods, including Western blotting for general exosome markers (CD63, CD9, CD81, and HSP70), NanoSight analysis, or EM (learn about different ways to detect exosomes and more in our Exosome Basics Guide).

The Bottom Line
With ExoQuick-TC, you can obtain high-quality exosomes from tissue culture media and certain biofluids using a protocol that can easily be performed on multiple samples and requires very low volumes of input sample.

REFERENCES

  1. Yang J, et al. Detection of Tumor Cell-Specific mRNA and Protein in Exosome-Like Microvesicles from Blood and Saliva. PLoS ONE. 2014. 9(11): e110641. PMCID: PMC 4232306.
  1. Alvarez ML. Isolation of urinary exosomes for RNA biomarker discovery using a simple, fast, and highly scalable method. Methods Mol Biol. 2014. 1182:145-70. PMID: 25055908.
  1. Sohel MM, et al. Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence. PLoS One. 2013 Nov 4. 8(11):e78505. PMCID: PMC3817212.
  1. Zhu L, et al. Novel method for extracting exosomes of hepatocellular carcinoma cells. World J Gastroenterol. 2014 June 7. 20(21): 6651-6657. PMCID: PMC4047354.
  1. Gu Y, et al. Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes. PLoS ONE. 2012. 7(8): e43691. PMCID: PMC3427246.

 

Supporting Data

Supporting Data

Characterizing ExoQuick-TC exosomes with NanoSight

Exosomes purified with ExoQuick-TC from tissue culture media show the expected particle size distribution and high concentration yields when analyzed using NanoSight’s Nanoparticle Tracking Analysis (NTA, Figure 1).

ExoQuick-TC delivers high yields of particles consistent in size with exosomes

Figure 3.Exosome size distribution and yields from tissue culture media. Cells from a human HT1080 lung sarcoma cell line were cultured in conditioned media (serum-free) for 72 hours. 10 mL of media was combined with 2 mL ExoQuick-TC, incubated overnight at 4°C, and centrifuged at 1500g for 30 minutes to isolate exosomes. The exosome pellet was resuspended in 1 mL PBS, diluted 1:40, and visualized on the NanoSight LM10 instrument. The analysis shows that ExoQuick-TC recovered 133 nm exosomes at a concentration of 1.74 x 109 particles/mL.

Resources

Citations

  • Lee, J, et al. (2022) Exosome-Mediated Delivery of Transforming Growth Factor-β Receptor 1 Kinase Inhibitors and Toll-Like Receptor 7/8 Agonists for Combination Therapy of Tumors. Acta Biomaterialia. 1970 Jan 1;. Link: Acta Biomaterialia
  • Tan, J, et al. (2022) DRAM1 increases the secretion of PKM2-enriched EVs from hepatocytes to promote macrophage activation and disease progression in ALD. Molecular Therapy - Nucleic Acids. 1970 Jan 1; 27:375-389. Link: Molecular Therapy - Nucleic Acids
  • Romanò, S, et al. (2022) Label-free spectroscopic characterization of exosomes reveals cancer cell differentiation. Analytica Chimica Acta. 1970 Jan 1; 1192:339359. Link: Analytica Chimica Acta
  • Zhang, C, et al. (2022) Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts. Cell death & disease. 1970 Jan 1; 13(1):57. PM ID: 35027547
  • Kis, D, et al. (2022) Extracellular Vesicles Derived from Bone Marrow in an Early Stage of Ionizing Radiation Damage Are Able to Induce Bystander Responses in the Bone Marrow. Cells. 1970 Jan 1; 11(1). PM ID: 35011718
  • Zhou, W, et al. (2022) Exosomal lncRNA and mRNA profiles in polycystic ovary syndrome: bioinformatic analysis reveals disease-related networks. Reproductive BioMedicine Online. 1970 Jan 1;. Link: Reproductive BioMedicine Online
  • Segura-Benítez, M, et al. (2022) Proteomic analysis of extracellular vesicles secreted by primary human epithelial endometrial cells reveals key proteins related to embryo implantation. Reproductive biology and endocrinology : RB&E. 1970 Jan 1; 20(1):3. PM ID: 34980157
  • Yang, Z, et al. (2022) Wavelength Tunable Aqueous CsPbBr3-Based Nanoprobes with Ultrahigh Photostability for Targeted Super-Resolution Bioimaging. ACS applied materials & interfaces. 1970 Jan 1; 14(15):17109-17118. PM ID: 35380800
  • Novello, S, et al. (2022) Influence of Periodontal Ligament Stem Cell-Derived Conditioned Medium on Osteoblasts. Pharmaceutics. 1970 Jan 1; 14(4). PM ID: 35456563
  • Rather, HA, et al. (2022) Mass Spectrometry-Based Proteome Profiling of Extracellular Vesicles Derived from the Cerebrospinal Fluid of Adult Rhesus Monkeys Exposed to Cocaine throughout Gestation. Biomolecules. 1970 Jan 1; 12(4). PM ID: 35454099
  • Sun, B, et al. (2022) Engineered induced-pluripotent stem cell derived monocyte extracellular vesicles alter inflammation in HIV humanized mice. Extracellular Vesicles and Circulating Nucleic Acids. 1970 Jan 1; 3(2):118-132. Link: Extracellular Vesicles and Circulating Nucleic Acids
  • Gao, Q, et al. (2022) Gastric cancer-derived exosomes induce PD-L1 expression on human bone marrow mesenchymal stem cells through the AKT-c-Myc signal axis. All Life. 1970 Jan 1; 15(1):442-451. Link: All Life
  • 최상헌, , et al. (2022) 유방암세포에서 세포외 소포체 분비 감소를 통한 glabridin 의 항암효과. Thesis. 1970 Jan 1;. Link: Thesis
  • Kang, M, et al. (2022) Extracellular Vesicles From TNFα Preconditioned MSCs: Effects on Immunomodulation and Bone Regeneration. Frontiers in immunology. 1970 Jan 1; 13:878194. PM ID: 35585987
  • Chen, J, et al. (2022) Adipose stem cells-released extracellular vesicles as a next-generation cargo delivery vehicles: a survey of minimal information implementation, mass production and functional modification. Stem cell research & therapy. 1970 Jan 1; 13(1):182. PM ID: 35505389
  • Zhu, J, et al. (2022) Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1. Oxidative medicine and cellular longevity. 1970 Jan 1; 2022:8392313. PM ID: 35615580
  • Tarasiuk, O, et al. (2022) Making Connections: Mesenchymal Stem Cells Manifold Ways to Interact with Neurons. International journal of molecular sciences. 1970 Jan 1; 23(10). PM ID: 35628600
  • Cai, Y, et al. (2022) Bone Marrow-Derived Mesenchymal Stem Cell-Derived Exosomes Containing Gli1 Alleviate Microglial Activation and Neuronal Apoptosis In Vitro and in a Mouse Parkinson Disease Model by Direct Inhibition of Sp1 Signaling. Journal of neuropathology and experimental neurology. 1970 Jan 1;. PM ID: 35609560
  • Inagaki, M & Tachikawa, M. (2022) Transport Characteristics of Placenta-Derived Extracellular Vesicles and Their Relevance to Placenta-to-Maternal Tissue Communication. Chemical & pharmaceutical bulletin. 1970 Jan 1; 70(5):324-329. PM ID: 35491187
  • Huang, MB, et al. (2022) Improved Aitongxiao prescription (I-ATXP) induces apoptosis, cell cycle arrest and blocks exosomes release in hepatocellular carcinoma (HCC) cells. International journal of physiology, pathophysiology and pharmacology. 1970 Jan 1; 14(2):90-113. PM ID: 35619665

Products

Catalog Number Description Size Price Quantity Add to Cart
EXOTC10A-1 ExoQuick-TC 10 mL $334
- +
EXOTC50A-1 ExoQuick-TC 50 mL $1124
- +

Overview

Overview

A better way to isolate exosomes

"We therefore pursued the ExoQuick® method for further study, as these samples required much less sample input, a key benefit when working with clinical samples and mouse models1."

Need exosomes? SBI's ExoQuick-TC enables high-throughput, quantitative isolation of exosomes from low volumes (as little as 1 ml) of tissue culture media and certain biofluids (saliva, urine, follicular fluid, and breast milk). Note, to isolate exosomes from serum, plasma, or ascites fluid, use the original ExoQuick formulation (EXOQ5A-1 or EXOQ20A-1). Compatible with a wide variety of downstream applications, ExoQuick-TC is an effective and proven alternative to ultracentrifugation1-3.

ExoQuick-TC’s fast, ultracentrifugation-free method:

  • Saves time and labor
  • Is easily scalable
  • Conserves precious sample
  • Delivers high yields of functional, high quality exosomes
  • Can be used to isolate exosomes for a wide range of downstream applications, including
    • Biomarker studies
    • Exosomal miRNA profiling
    • Exosomal proteomics
    • Exosomal lipidomics/metabolomics
    • Functional studies, such as in cell-to-cell signaling
    • Basic biology, such as role in tumorigenesis

ExoQuick-TC is a proprietary polymer that gently precipitates exosomes. First, pre-clear your samples of cells and cellular debris, and then simply add the appropriate amount of ExoQuick-TC to your cleared biofluid, refrigerate, and centrifuge (see the product manual for protocol details). Your exosomes will be in the pellet, ready for resuspension in an appropriate solution.

BiofluidSample volumeExoQuick-TC Volume
Tissue culture media, urine, cerebrospinal fluid (CSF), etc.5 mL1 mL

In electron microscopy studies, exosomes isolated with ExoQuick-TC appear similar to exosomes isolated using ultracentrifugation1-2, and these exosomes are also active in numerous functional assays1-3.

Exosomes isolated with ExoQuick-TC can be used for all types of protein profiling and protein characterization studies, such as mass spectrometry, Western blotting, ELISA, and more. Higher protein yields are achieved by ExoQuick purification than by chromatography, DynaBeads, or ultracentrifugation.

Exosomes isolated with ExoQuick-TC also provide excellent samples for studying exosome-associated nucleic acids such as microRNAs, siRNAs, and even mRNA. Quantitative analytical techniques such as qPCR, microarray studies, and next-generation sequencing are all compatible with nucleic acids isolated from ExoQuick-TC-purified exosomes.

Backed by a growing number of publications, ExoQuick-TC is often the best option for researchers working with low sample volumes, such as clinical research samples or small animal models.

ExoQuick-TC exosome isolation methods are patented technologies4.

Choose the right ExoQuick for your application:

ApplicationProductCatalog #
Purest EV isolationExoQuick ULTRA and
ExoQuick-TC ULTRA
EQULTRA-20A-1
EQULTRA-20TC-1
General purpose EV isolationExoQuick and
ExoQuick-TC
EXOQ20A-1
EXOTC50A-1
EV isolation for pre-clinical/in vivo studiesExoQuick-CGEXOCG50A-1
EV isolation that removes contaminating lipoprotein particles from plasma or serumExoQuick-LPEXOLP5A-1
EV isolation that includes a de-fibrinating plasma step prior to isolationExoQuick Plasma Prep with ThrombinEXOQ5TM-1

REFERENCES

  1. Chugh PE, et al. Systemically Circulating Viral and Tumor-Derived MicroRNAs in KSHV-Associated Malignancies. PLoS Pathog. 2013. 9(7): e1003484. PMCID: PMC3715412.
  1. Umezu T, et al. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene. 2013 May 30. 32(22):2747-55. PMID: 22797057.
  1. Sohel MM, et al. Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence. PLoS One. 2013 Nov 4. 8(11):e78505. PMCID: PMC3817212.
  1. Antes T, et al. Methods for Microvesicle Isolation and Selective Removal. Patent No.: US 9,005,888 B2.

How It Works

How It Works

High-throughput, quantitative exosome recovery

ExoQuick-TC can be used to purify exosomes from a wide variety of tissue culture media4, and from certain biofluids such as saliva1, urine2, follicular fluid3, and breast milk5. With a simple workflow involving minimal hands-on time and low input sample volume requirements, ExoQuick-TC is an excellent option for researchers who need to purify multiple exosome samples.

To isolate exosomes from tissue culture media, simply:

  • Add an appropriate volume of ExoQuick-TC
  • Incubate overnight at 4°C
  • Isolate exosomes with a 30-minute low-speed spin (1500g).

Isolated exosomes can be found in the pellet and resuspended in an appropriate solution.

A quick and easy exosome isolation workflow

You can verify the presence of exosomes with a number of different methods, including Western blotting for general exosome markers (CD63, CD9, CD81, and HSP70), NanoSight analysis, or EM (learn about different ways to detect exosomes and more in our Exosome Basics Guide).

The Bottom Line
With ExoQuick-TC, you can obtain high-quality exosomes from tissue culture media and certain biofluids using a protocol that can easily be performed on multiple samples and requires very low volumes of input sample.

REFERENCES

  1. Yang J, et al. Detection of Tumor Cell-Specific mRNA and Protein in Exosome-Like Microvesicles from Blood and Saliva. PLoS ONE. 2014. 9(11): e110641. PMCID: PMC 4232306.
  1. Alvarez ML. Isolation of urinary exosomes for RNA biomarker discovery using a simple, fast, and highly scalable method. Methods Mol Biol. 2014. 1182:145-70. PMID: 25055908.
  1. Sohel MM, et al. Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence. PLoS One. 2013 Nov 4. 8(11):e78505. PMCID: PMC3817212.
  1. Zhu L, et al. Novel method for extracting exosomes of hepatocellular carcinoma cells. World J Gastroenterol. 2014 June 7. 20(21): 6651-6657. PMCID: PMC4047354.
  1. Gu Y, et al. Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes. PLoS ONE. 2012. 7(8): e43691. PMCID: PMC3427246.

 

Supporting Data

Supporting Data

Characterizing ExoQuick-TC exosomes with NanoSight

Exosomes purified with ExoQuick-TC from tissue culture media show the expected particle size distribution and high concentration yields when analyzed using NanoSight’s Nanoparticle Tracking Analysis (NTA, Figure 1).

ExoQuick-TC delivers high yields of particles consistent in size with exosomes

Figure 3.Exosome size distribution and yields from tissue culture media. Cells from a human HT1080 lung sarcoma cell line were cultured in conditioned media (serum-free) for 72 hours. 10 mL of media was combined with 2 mL ExoQuick-TC, incubated overnight at 4°C, and centrifuged at 1500g for 30 minutes to isolate exosomes. The exosome pellet was resuspended in 1 mL PBS, diluted 1:40, and visualized on the NanoSight LM10 instrument. The analysis shows that ExoQuick-TC recovered 133 nm exosomes at a concentration of 1.74 x 109 particles/mL.

Citations

  • Lee, J, et al. (2022) Exosome-Mediated Delivery of Transforming Growth Factor-β Receptor 1 Kinase Inhibitors and Toll-Like Receptor 7/8 Agonists for Combination Therapy of Tumors. Acta Biomaterialia. 1970 Jan 1;. Link: Acta Biomaterialia
  • Tan, J, et al. (2022) DRAM1 increases the secretion of PKM2-enriched EVs from hepatocytes to promote macrophage activation and disease progression in ALD. Molecular Therapy - Nucleic Acids. 1970 Jan 1; 27:375-389. Link: Molecular Therapy - Nucleic Acids
  • Romanò, S, et al. (2022) Label-free spectroscopic characterization of exosomes reveals cancer cell differentiation. Analytica Chimica Acta. 1970 Jan 1; 1192:339359. Link: Analytica Chimica Acta
  • Zhang, C, et al. (2022) Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts. Cell death & disease. 1970 Jan 1; 13(1):57. PM ID: 35027547
  • Kis, D, et al. (2022) Extracellular Vesicles Derived from Bone Marrow in an Early Stage of Ionizing Radiation Damage Are Able to Induce Bystander Responses in the Bone Marrow. Cells. 1970 Jan 1; 11(1). PM ID: 35011718
  • Zhou, W, et al. (2022) Exosomal lncRNA and mRNA profiles in polycystic ovary syndrome: bioinformatic analysis reveals disease-related networks. Reproductive BioMedicine Online. 1970 Jan 1;. Link: Reproductive BioMedicine Online
  • Segura-Benítez, M, et al. (2022) Proteomic analysis of extracellular vesicles secreted by primary human epithelial endometrial cells reveals key proteins related to embryo implantation. Reproductive biology and endocrinology : RB&E. 1970 Jan 1; 20(1):3. PM ID: 34980157
  • Yang, Z, et al. (2022) Wavelength Tunable Aqueous CsPbBr3-Based Nanoprobes with Ultrahigh Photostability for Targeted Super-Resolution Bioimaging. ACS applied materials & interfaces. 1970 Jan 1; 14(15):17109-17118. PM ID: 35380800
  • Novello, S, et al. (2022) Influence of Periodontal Ligament Stem Cell-Derived Conditioned Medium on Osteoblasts. Pharmaceutics. 1970 Jan 1; 14(4). PM ID: 35456563
  • Rather, HA, et al. (2022) Mass Spectrometry-Based Proteome Profiling of Extracellular Vesicles Derived from the Cerebrospinal Fluid of Adult Rhesus Monkeys Exposed to Cocaine throughout Gestation. Biomolecules. 1970 Jan 1; 12(4). PM ID: 35454099
  • Sun, B, et al. (2022) Engineered induced-pluripotent stem cell derived monocyte extracellular vesicles alter inflammation in HIV humanized mice. Extracellular Vesicles and Circulating Nucleic Acids. 1970 Jan 1; 3(2):118-132. Link: Extracellular Vesicles and Circulating Nucleic Acids
  • Gao, Q, et al. (2022) Gastric cancer-derived exosomes induce PD-L1 expression on human bone marrow mesenchymal stem cells through the AKT-c-Myc signal axis. All Life. 1970 Jan 1; 15(1):442-451. Link: All Life
  • 최상헌, , et al. (2022) 유방암세포에서 세포외 소포체 분비 감소를 통한 glabridin 의 항암효과. Thesis. 1970 Jan 1;. Link: Thesis
  • Kang, M, et al. (2022) Extracellular Vesicles From TNFα Preconditioned MSCs: Effects on Immunomodulation and Bone Regeneration. Frontiers in immunology. 1970 Jan 1; 13:878194. PM ID: 35585987
  • Chen, J, et al. (2022) Adipose stem cells-released extracellular vesicles as a next-generation cargo delivery vehicles: a survey of minimal information implementation, mass production and functional modification. Stem cell research & therapy. 1970 Jan 1; 13(1):182. PM ID: 35505389
  • Zhu, J, et al. (2022) Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1. Oxidative medicine and cellular longevity. 1970 Jan 1; 2022:8392313. PM ID: 35615580
  • Tarasiuk, O, et al. (2022) Making Connections: Mesenchymal Stem Cells Manifold Ways to Interact with Neurons. International journal of molecular sciences. 1970 Jan 1; 23(10). PM ID: 35628600
  • Cai, Y, et al. (2022) Bone Marrow-Derived Mesenchymal Stem Cell-Derived Exosomes Containing Gli1 Alleviate Microglial Activation and Neuronal Apoptosis In Vitro and in a Mouse Parkinson Disease Model by Direct Inhibition of Sp1 Signaling. Journal of neuropathology and experimental neurology. 1970 Jan 1;. PM ID: 35609560
  • Inagaki, M & Tachikawa, M. (2022) Transport Characteristics of Placenta-Derived Extracellular Vesicles and Their Relevance to Placenta-to-Maternal Tissue Communication. Chemical & pharmaceutical bulletin. 1970 Jan 1; 70(5):324-329. PM ID: 35491187
  • Huang, MB, et al. (2022) Improved Aitongxiao prescription (I-ATXP) induces apoptosis, cell cycle arrest and blocks exosomes release in hepatocellular carcinoma (HCC) cells. International journal of physiology, pathophysiology and pharmacology. 1970 Jan 1; 14(2):90-113. PM ID: 35619665