ExoGlowTM-Membrane EV Labeling Kit

Label EV membranes (465 nm excitation/635 nm emission) with a reagent specifically optimized for EV labeling.

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ExoGlowTM-Membrane EV Labeling Kit

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ExoGlowTM-Membrane EV Labeling Kit

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25 Reactions
EXOGM600A-1
$ 295
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Overview

See EVs better with reagents specifically optimized for labeling
SBI’s new generation of extracellular vesicle (EV) labeling reagents take your EV visualization to new levels of clarity, with low background and high selectivity. Unlike general-purpose labeling reagents that are not optimized for EVs and suffer from high levels of background signal, ExoGlowTM-Membrane improves your ability to track and localize EVs by specifically labeling EV membranes with a proprietary fluorescent dye that delivers very low levels of background signal. The result is unmatched EV imaging for more accurate studies (see below for our full range of next generation ExoGlow reagents).

  • Specific—carefully developed to generate a robust signal specific for EV membranes, leading to very low levels of background
  • Compatible—delivers robust performance on EVs isolated using all methods tested—including ExoQuick®, ultracentrifugation, and column-based workflows
  • Easy-to-use—labeling protocol is quick and straightforward
  • Powerful—can be used with as little as 1 µg of EVs

ExoGlow-Membrane properties:
Excitation: 465 nm
Emission: 635 nm
Laser line: 488 nm

Available next generation ExoGlow EV imaging reagents

EV Component Labeled Cat. # Product Excitation (nm) Emission (nm) Laser Line (nm)
Internal protein EXOGP100A-1 ExoGlow-Protein EV Labeling Kit (Red) 573 588 561
EXOGP300A-1 ExoGlow-Protein EV Labeling Kit (Green)

511 525 488
EXOGP400A-1 ExoGlow-Protein EV Labeling Kit (Blue) 403 454 405
RNA EXOGR800A-1 ExoGlow-RNA EV Labeling Kit 485 537 488
Membrane EXOGM600A-1 ExoGlow-Membrane EV Labeling Kit 465 635 488

Supporting Data

Imaging EVs with a new level of clarity

ExoGlow-Membranes enables clear visualization of labeled EVs being internalized by target cells

Figure 1. ExoGlow-Membrane enables clear visualization of labeled EVs being internalized by target cells. We labeled HEK293T EVs with ExoGlow-Membrane and followed uptake by HEK293T cells. The evenly distributed fluorescence signal shows internalization of labeled EVs by the target cells and the distribution of EV membranes to cellular membranes.

ExoGlow-Membranes enables clear visualization of labeled EVs being internalized by target cells

Figure 2. ExoGlow-Membrane is specific for intact membranes. We incubated either PBS, liposomes, liposomes pre-solubilized with detergent (0.05% Tx100), EVs, or lipoproteins. Only the samples with intact membranes—liposomes and EVs (blue)—show a high fluorescence signal, demonstrating ExoGlow-Membrane’s specificity for intact membranes.