Exo-CheckTM Exosome Antibody Array (Neuro)

Streamline detection of exosomes derived from neurons with Exo-CheckTM Exosome Antibody Neuro Arrays.

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Exo-Check Exosome Antibody Array (Neuro) Standard

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Exo-Check Exosome Antibody Array (Neuro) Standard

[variation_id] => 87792 [variation_is_active] => 1 [variation_is_visible] => 1 [weight] => [weight_html] => N/A )
4 Arrays
EXORAY500A-4
$ 575

Exo-Check Exosome Antibody Array (Neuro) Standard

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Exo-Check Exosome Antibody Array (Neuro) Standard

[variation_id] => 87793 [variation_is_active] => 1 [variation_is_visible] => 1 [weight] => [weight_html] => N/A )
8 Arrays
EXORAY500A-8
$ 995

Exo-Check Exosome Antibody Array (Neuro) Mini

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Exo-Check Exosome Antibody Array (Neuro) Mini

[variation_id] => 87795 [variation_is_active] => 1 [variation_is_visible] => 1 [weight] => [weight_html] => N/A )
4 Arrays
EXORAY510A-4
$ 375

Exo-Check Exosome Antibody Array (Neuro) Mini

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Exo-Check Exosome Antibody Array (Neuro) Mini

[variation_id] => 87796 [variation_is_active] => 1 [variation_is_visible] => 1 [weight] => [weight_html] => N/A )
8 Arrays
EXORAY510A-8
$ 649
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Overview

Building deep insights from exosomes—confirm neuronal markers

Whether you’re interested in biomarker discovery, studying normal neural processes, or unraveling the biological basis for neurological diseases, exosomes shed by neural cells can provide critical data and key insights. To help researchers quickly and efficiently identify exosomes carrying neuronal markers, SBI now offers the Exo-Check Exosome Antibody Array (Neuro), an extension of our popular and effective Exo-Check Array technology that enables antibody-based detection of many targets in parallel with the convenience and simplicity of a membrane-based dot-blot.

Available as a comprehensive standard array with 11 targets and 3 controls (Tables 1 and 3), as well as a sample-saving mini array, with 5 targets and 3 controls (Tables 2 and 3), the Exo-Check Exosome Antibody Array (Neuro) enables sensitive detection of both exosome-specific and neuron-specific markers in a single experiment. Use as little as 10 µg of total protein from EV-containing lysates and efficiently get the answers you need.

  • Sensitive—use as little as 10 µg of input protein for profiling general EV and neuronal-associated markers
  • Intuitive—provided in a simple, easy-to-use membrane-based dot-blot array format
  • Scalable—profile up to 11 targets and 3 controls without the hassle of western blotting
  • Compatible—suitable for EVs isolated using column-based/SEC methods, ultracentrifugation, and precipitation, as well as immuno-affinity captured EVs
  • Evidence-based—targets are carefully chosen from the literature and have been shown to be associated with EVs

A guide to our Exo-Check Exosome Array (Neuro) antibodies
Table 1. Standard Kit

Column 1Column 2
BlankPositive control
CD63L1CAM
CD9NCAM1
CD81ENO2
TSG101MAPT
CANXGRIA1
ICAM1PLP1

Table 2. Mini Kit
Column 1Column 2
BlankPositive control
CD81L1CAM
TSG101ENO2
CANXMAPT

Table 3. A guide to Target Proteins
Standard Array Spot position1Mini Array Spot position1IDDescriptionTypeLink to ExoCarta entry for the human protein
A1A1BlankBackground controlNEG2
A2CD63LAMP-3, Tetraspanin 30EXO3ExoCarta 967
A3CD9Tetraspanin 29EXOExoCarta 928
A4A2CD81Tetraspanin 28EXOExoCarta 975
A5A3TSG101VPS23, Tumor susceptibility gene 101EXOExoCarta 7251
A6A4CANXCalnexinCON4Uniprot P27824
A7ICAM1CD54, Intracellular adhesion molecule 1EXOExoCarta 3383
B1B1Positive controlPositive control for HRP detectionPOS6
B2B2L1CAMCD171, L1 transmembrane proteinNEVExoCarta 3897
B3NCAM1CD56 Neural cell adhesion moleculeNEVExoCarta 4684
B4B3ENO2Enolase 2NEVExoCarta 2026
B5B4MAPTTotal tau proteinNEVPMID: 22057275
B6GRIA1Glutamate receptor 1NEVPMID: 17189949
B7PLP1Proteolipid protein 1NEVExoCarta 5354
1. To correctly orient the array, place the notched corner in the upper left-hand position
2. NEG = Negative control
3. EXO = General exosome marker
4. CON = Cellular contamination control
5. NEV = Neuronal-associated EV marker

Supporting Data

See our neuro Exo-Check Antibody Arrays in action

Sample Exo-Check Antibody Array (Neuro) data showing exosome detection and confirmation of the presence of neuronal markers

Sample Exo-Check Antibody Array (Neuro) data showing exosome detection and confirmation of the presence of neuronal markers. (A) EVs were isolated from 250 µl of pooled human serum using SBI’s ExoQuick Reagent, and 10 µg of EV-associated protein were loaded onto a standard Exo-Check Neuro Array. (B) EVs were isolated from 250 µl of a different pooled human serum sample and 50 µg of EV-associated protein were loaded onto a mini Exo-Check Neuro Array.

The Exo-Check Neuro Array is sensitive, providing robust and reproducible signal from as a little as 10 µg of input sample

The Exo-Check Neuro Array is sensitive, providing robust and reproducible signal from as a little as 10 µg of input sample. EVs were isolated from 250 µl of human serum using ExoQuick Reagent ,and either 10 µg, 20 µg, or 50 µg of EV-associated protein were loaded onto a standard array.