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SBI and Transposagen release PiggyBac Transposon Vectors

Mountain View, CA—05-01-2011 - TRANSPOSAGEN BIOPHARMACEUTICALS, INC. LEXINGTON AND MOUNTAIN VIEW, KY, CA UNITED STATES
LEXINGTON, Ky., and MOUNTAIN VIEW, Calif., May 11, 2011 /PRNewswire/ -- Transposagen Biopharmaceuticals, Inc. (Transposagen) and System Biosciences (SBI), both leaders in genetic modification technology, have announced a non-exclusive marketing and distribution agreement between the two biotechnology companies involving Transposagen's piggyBac technology.

The piggyBac Genetic Modification System enables researchers to:
Alter the genomes of numerous animal species with a simple transfection Reprogram somatic cells into induced pluripotent stem (iPS) cells Perform highly efficient and cost-effective non-viral gene delivery Reverse genomic modifications with footprint-free transposon removal

The piggyBac DNA transposon technology is already being utilized in multiple research areas, such as gene therapy, regenerative medicine, cell line engineering, and animal model creation. "We are excited to add the world's most efficient and cost-effective non-viral reprogramming technology to our already impressive catalog of stem cell and microRNA research reagents," said Dr. Travis Antes, the Director of Product Development at SBI.
Researchers in academia and the pharmaceutical and biotechnology industries can now purchase piggyBac vectors produced with SBI's high standards of manufacturing and quality control. Transposagen's piggyBac technology will be paired with SBI's existing leading-edge technologies to further broaden the utility of piggyBac. SBI will also use piggyBac in custom vectors and cell lines for customers. Furthermore, Transposagen and SBI have agreed to collaborate in the production of custom transgenic rats. The collaboration will combine SBI's genomic tools and expertise with Transposagen's piggyBac and rat spermatogonial stem cell technology. Researchers will now have access to specialized transgenic rats incorporating SBI's reagents, such as species-specific RNAi, MicroRNAs or anti-MicroRNAs. Rat models with inducible gene expression can also be produced using SBI's SparQ cumate switch system, the first inducible system that can be induced with a small molecule that can readily cross the blood-brain and blood-testis barriers. "The combination of Transposagen and SBI's innovative technologies will now allow researchers to make sophisticated transgenic rat models that may mimic human diseases better than in the past," said Eric Ostertag, President and CEO of Transposagen.
About Transposagen Biopharmaceuticals:
Transposagen Biopharmaceuticals, Inc., a Lexington, KY-based company, is the worldwide leader in the creation of unique genetically modified rat models. The company's signature products, TKO Knockout Rat Models and TGEM Rat Models, mimic human diseases and are used for drug discovery and development research. The company also creates custom transgenic rat models and custom knockout rat models to customer specifications. For more information or to request a custom rat model, visit www.transposagenbio.com.
About System Biosciences (SBI):
System Biosciences (SBI) specializes in developing unique, innovative technologies to provide researchers with the tools to investigate and understand genomic and proteomic function. SBI offers solutions for Lentiviral, Minicircle and piggyBac-mediated gene delivery and knockdown, high-throughput RNAi screens and products for Stem Cell and MicroRNA research. For more information, visit www.systembio.com.

Transposagen Contact:
Jack Crawford
145 Graham Avenue, A217
Lexington, KY 40506
315-351-9115
jcrawford@transposagenbio.com
www.transposagenbio.com

System Biosciences Contact:
Jake Lesnik
265 North Whisman Rd.
Mountain View, CA 94043
650-968-2200
jlesnik@systembio.com