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Katey J. Rayner, Yajaira Suárez, Alberto Dávalos, Saj Parathath, Michael L. Fitzgerald, Norimasa Tamehiro, Edward A. Fisher,Kathryn J. Moore, Carlos Fernández-Hernando. miR-33 Contributes to the Regulation of Cholesterol Homeostasis. Science. 2010 Jun 18;328(5985):1570-3.

Hollander JA, Im HI, Amelio AL, Kocerha J, Bali P, Lu Q, Willoughby D, Wahlestedt C, Conkright MD, Kenny PJ. Striatal microRNA controls cocaine intake through CREB signalling. Nature. 2010 Jul 8;466(7303):197-202.

Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM. MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci USA. 2010 Dec 7;107(49):21098-103. (PDF) »

Hassan MQ, Gordon JA, Beloti MM, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program. Proc Natl Acad Sci U S A. 2010 Oct 27. [Epub ahead of print]. (PDF) »

Heh-In Im, Jonathan A Hollander, Purva Bali and Paul J Kenny. MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Nature Neuroscience. 2010 Aug 15. [Epub ahead of print].

Wilson KD, Hu S, Venkatasubrahmanyam S, Fu JD, Sun N, Abilez OJ, Baugh JJ, Jia F, Ghosh Z, Li RA, Butte AJ, Wu JC. Dynamic MicroRNA Expression Programs during Cardiac Differentiation of Human Embryonic Stem Cells: Role for miR-499. Circ Cardiovasc Genet. 2010 Aug 23. [Epub ahead of print].

Masakazu Kamata, Min Liang, Shirley Liu, Yoshiko Nagaoka and Irvin S. Y. Chen. Live Cell Monitoring of hiPSC Generation and Differentiation Using Differential Expression of Endogenous microRNAs. PLoS One. 2010; 5(7): e11834. (PDF) »

Valeri N, Gasparini P, Fabbri M, Braconi C, Veronese A, Lovat F, Adair B, Vannini I, Fanini F, Bottoni A, Costinean S, Sandhu SK, Nuovo GJ, Alder H, Gafa R, Calore F, Ferracin M, Lanza G, Volinia S, Negrini M, McIlhatton MA, Amadori D, Fishel R, Croce CM. Modulation of mismatch repair and genomic stability by miR-155. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6982-7. (PDF) »

Kotaro Sasaki, Gary Kohanbash, Aki Hoji, Ryo Ueda, Heather A McDonald, Todd A Reinhart, Jeremy Martinson, Michael T Lotze, Francesco M Marincola, Ena Wang, Mitsugu Fujita, Hideho Okada. miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy. Journal of Translational Medicine 2010, 8:17. (PDF) »

Kong W, He L, Coppola M, Guo J, Esposito NN, Coppola D, Cheng JQ. MicroRNA-155 regulates cell survival, growth and chemosensitivity by targeting FOXO3a in breast cancer. J Biol Chem. 2010 Apr 6. [Epub ahead of print]. (PDF) »

Hasan Rajabi,Caining Jin,Rehan Ahmad,Andrew Cain McClary,Maya Datt Joshi and Donald Kufe. Mucin 1 Oncoprotein Expression Is Suppressed by the miR-125b Oncomir. Genes and Cancer Jan 2010, vol. 1 no. 1 62-68. (PDF) »

Gururajan M, Haga CL, Das S, Leu CM, Hodson D, Josson S, Turner M, Cooper MD. MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int Immunol. 2010 May 23. [Epub ahead of print]

Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 2009 Aug 6;460(7256):705-10.

Xiaowei Wang. A PCR-based platform for microRNA expression profiling studies. RNA (2009), 15:716�723. (PDF) »

Li X, Shen Y, Ichikawa H, Antes T, Goldberg GS. Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration. Oncogene. (2009 Sep 21): 1-12.

Ramiro Garzon, Shujun Liu, Muller Fabbri, Zhongfa Liu, Catherine E.A. Heaphy, Elisa Callegari, Sebastian Schwind, Jiuxia Pang, Jianhua Yu, Natarajan Muthusamy, Violaine Havelange, Stefano Volinia, William Blum, Laura J. Rush, Danilo Perrotti, Michael Andreeff, Clara D. Bloomfield, John C. Byrd, Kenneth Chan, Lai-Chu Wu, Carlo M. Croce, and Guido Marcucci. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood, 18 June 2009, Vol. 113, No. 25, pp. 6411-6418.

Dongsheng Yan, Xiang Da (Eric) Dong, Xiaoyan Chen, Lihua Wang, Chunjing Lu, Jiao Wang, Jia Qu, and LiLi Tu. MicroRNA-1/206 Targets c-Met and Inhibits Rhabdomyosarcoma Development. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 284, NO. 43, pp. 29596�29604, October 23, 2009.

Can-Jie Guo, Qin Pan, Bo Jiang, Guang-Yu Chen and Ding-Guo Li. Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells. Apoptosis (2009) 14:1331�1340. (PDF) »

Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, Li Z, Wu Z, Pei G. MicroRNA miR-326 regulates T(H)-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol. 2009 Oct 18.

Qing Ji, Xinbao Hao, Min Zhang, Wenhua Tang, Meng Yang, Ling Li, Debing Xiang, Jeffrey T. DeSano, Guido T. Bommer, Daiming Fan, Eric R. Fearon, Theodore S. Lawrence, Liang Xu. MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells. PLoS ONE 4(8): e6816 (2009).

Manjunatha R. Benakanakere, Qiyan Li, Mehmet A. Eskan, Amar V. Singh, Jiawei Zhao, Johnah C. Galicia, Panagiota Stathopoulou, Thomas B. Knudsen, and Denis F. Kinane. Modulation of TLR2 Protein Expression by miR-105 in Human Oral Keratinocytes. J. Biol. Chem., Vol. 284, Issue 34, 23107-23115, August 21, 2009. (PDF) »

Lu TX, Munitz A, Rothenberg ME. MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol. 2009 Apr 15;182(8):4994-5002. (PDF) »

Yuan-Hau Tsai, Min-Fen Wu, Yu-Hsuan Wu, Shing-Jyh Chang, Su-Fang Lin, Tyson V. Sharp and Hsei-Wei Wang. The M Type K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus Regulates MicroRNA Expression via Its SH2-Binding Motif To Induce Cell Migration and Invasion. Journal of Virology, January 2009, p. 622-632, Vol. 83, No. 2 (PDF) »

Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY. p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc Natl Acad Sci U S A. 2009 Mar 3; 106(9):3207-12. (PDF) »

Z Lu, M Liu, V Stribinskis, CM Klinge, KS Ramos, NH Colburn and Y Li. MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene (2008) 27, 4373-4379. (PDF) »

Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, Raychaudhury A, Newton HB, Chiocca EA, Lawler S. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 2008 Nov 15;68(22):9125-30. (PDF) »

Qing Ji, Xinbao Hao, Yang Meng, Min Zhang, Jeffrey DeSano, Daiming Fan and Liang Xu. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer 2008, 8:266 doi:10.1186/1471-2407-8-266. (PDF) »

Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 2007 Sep 15;67(18):8433-8. (PDF) »

 

MicroRNA Technical References

microRNA discovery

Lee RC, Feinbaum RL, Ambros V. “The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14”. Cell, 75:843-854, 1993.

Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvits HR, Ruvkun G. “The 21-nucleotides let-7 RNA regulates developmental timing in Caenorhabditis elegans”. Nature, 403:901-906, 2000.

Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. “Identification of novel genes coding for small expressed RNAs”. Science, 294:853-858, 2001.

microRNA targets prediction

Rhoades MW, Reinhart BJ, Lim LP, Burge CB, Bartel B, Bartel DP. “Prediction of plant microRNA targets”. Cell, 110:513-520, 2002.

Lewis BP, Burge CB, Bartel DP. “Conserved seed pairing, often flanking by adenosines, indicates that thousands of human genes are microRNA targets”. Cell, 120:15-20, 2005.

John, B., C. Sander and D. S. Marks (2006). "Prediction of human microRNA targets." Methods Mol Biol, 342: 101-13.

Vector-based microRNA expression

Mathijs Voorhoeve, P., C.L. Sage, M. Schrier, A.J.M.Gillis, H. Stoop, R.Nagel, Y. Liu, J.V.Duijse, J. Drost, A. Griekspoor, E. Zlotorynski, N. Yabuta, G. D.Vita, H. Nojima, L.H.J.Looijenga, and R. Agami (2006). “A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors.” Cell, 124, 1169-1181.

Shin, K. J., E. A. Wall, J. R. Zavzavadjian, L. A. Santat, J. Liu, J. I. Hwang, R. Rebres, T. Roach, W. Seaman, M. I. Simon and I. D. Fraser (2006). "A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression." PNAS U S A, 103(37): 13759-64.

Stegmeier, F., G. Hu, R. J. Rickles, G. J. Hannon and S. J. Elledge (2005). "A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells." PNAS U S A, 102(37): 13212-7.

Primary microRNA processing

Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN. “The Drosha-DGCR8 complex in primary microRNA processing”. Gene Develop, 18: 3016-3027, 2004.

Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT, Kim VN. “Molecular basis for the recognision of primary microRNAs by the Drosha-DGCR8 complex”. Cell, 125: 887-901.2006.

Zeng Y, Yi R, Cullen BR. “Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha”. EMBO J, 24:138-148, 2005.

Zeng Y, Cullen BR. “Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences”. J Bio Chem, 280:27595-27603, 2005.

microRNA functional study

Bennasser, Y., S. Y. Le, M. L. Yeung and K. T. Jeang (2004). "HIV-1 encoded candidate micro-RNAs and their cellular targets." Retrovirology, 1(1): 43.

Esau C, Kang X, Peralta E, Hanson E, Marcusson EG, Ravichandran LV, Sun Y, Koo S, Perera RJ, Jain R, Dean NM, Freier SM, Bennett CF, Lollo B, Griffey R. MicroRNA-143 regulates adipocyte differentiation. J Biol Chem. 2004 Dec 10;279(50):52361-5.

Hariharan, M., V. Scaria, B. Pillai and S. K. Brahmachari (2005). "Targets for human encoded microRNAs in HIV genes." Biochem Biophys Res Commun, 337(4): 1214-8.

Johnson, S. M., H. Grosshans, J. Shingara, M. Byrom, R. Jarvis, A. Cheng, E. Labourier, K. L. Reinert, D. Brown and F. J. Slack (2005). "RAS is regulated by the let-7 microRNA family." Cell, 120(5): 635-47.

Kim, V. N. (2005). "Small RNAs: classification, biogenesis, and function." Mol Cells, 19(1): 1-15.

Lee, R. C., R. L. Feinbaum and V. Ambros (1993). "The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14." Cell, 75(5): 843-54.

Lee, Y., K. Jeon, J. T. Lee, S. Kim and V. N. Kim (2002). "MicroRNA maturation: stepwise processing and subcellular localization." Embo J, 21(17): 4663-70.

Olsen, P. H. and V. Ambros (1999). "The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation." Dev Biol, 216(2): 671-80.

Pfeffer, S., M. Zavolan, F. A. Grasser, M. Chien, J. J. Russo, J. Ju, B. John, A. J. Enright, D. Marks, C. Sander and T. Tuschl (2004). "Identification of virus-encoded microRNAs." Science, 304(5671): 734-6.

Yi, R., Y. Qin, I. G. Macara and B. R. Cullen (2003). "Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs." Genes Dev, 17(24): 3011-6.