Online Resources

Product Citations

Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nagakami F, Heymann HM, Chernugobova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS. miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. Nat Commun. 2014 Oct 31;5:5214.

Finlay-Schultz J, Cittelly DM, Hendricks P, Patel P, Kabos P, Jacobsen BM, Richer JK, Sartorius CA. Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a. Oncogene. 2014 Sep 22;0. doi: 10.1038/onc.2014.298.

Uhde-Stone C, Sarkar N, Antes T, Otoc N, Kim Y, Jiang YJ, Lu B. A TALEN-based strategy for efficient bi-allelic miRNA ablation in human cells. RNA. 2014 Apr 9. [Epub ahead of print].

Mazan-Mamczarz K, Zhao XF, Dai B, Steinhardt JJ, Peroutka RJ, et al. Down-Regulation of eIF4GII by miR-520c-3p Represses Diffuse Large B Cell Lymphoma Development. PLoS Genet 10(1): e1004105. doi:10.1371/ journal.pgen.1004105.

Tsuno S, Wang X, Shomori K, Hasegawa J, Miura N. Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process. Sci Rep. 2014 Jan 24;4:3852.

Kang T, Lu W, Xu W, Anderson L, Bacanamwo M, Thompson W, Chen YE, Liu D. MicroRNA-27 (miR-27) Targets Prohibitin and Impairs Adipocyte Differentiation and Mitochondrial Function in Human Adipose-derived Stem Cells. J Biol Chem. 2013 Nov 29;288(48):34394-402.

Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC, Yao Q. A Tumorigenic Factor Interactome Connected through Tumor Suppressor MicroRNA-198 in Human Pancreatic Cancer. Clin Cancer Res. 2013 Nov 1;19(21):5901-13.

Borbone E, De Rosa M, Siciliano D, Altucci L, Croce CM, Fusco A. Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells. J Clin Endocrinol Metab. 2013 Jun;98(6):E1031-40.

Liu XS, Chopp M, Wang XL, Zhang L, Hozeska-Solgot A, Tang T, Kassis H, Zhang RL, Chen C, Xu J, Zhang ZG. MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke. J Biol Chem. 2013 May 3;288(18):12478-88.

Tran MN, Choi W, Wszolek MF, Navai N, Lee IL, Nitti G, Wen S, Flores ER, Siefker-Radtke A, Czerniak B, Dinney C, Barton M, McConkey DJ. The p63 protein isoform Delta-Np63-alpha inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205. J Biol Chem. 2013 Feb 1;288(5):3275-88.

Zhang LY, Ho-Fun Lee V, Wong AM, Kwong DL, Zhu YH, Dong SS, Kong KL, Chen J, Tsao SW, Guan XY, Fu L. MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. Carcinogenesis. 2013 Feb;34(2):454-63.

Wang G, Chen C, Yang R, Cao X, Lai S, Luo X, Feng Y, Xia X, Gong J, Hu J. p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-kB pathway. Angiogenesis. 2013 Jul;16(3):561-73.

Gong M, Ma J, Guillemette R, Zhou M, Yang Y, Yang Y, Hock JM, Yu X. miR-335 Inhibits Small Cell Lung Cancer Bone Metastases via IGF-1R and RANKL Pathways. Mol Cancer Res. 2013 Aug 21. [Epub ahead of print].

White RA, Neiman JM, Reddi A, Han G, Birlea S, Mitra D, Dionne L, Fernandez P, Murao K, Bian L, Keysar SB, Goldstein NB, Song N, Bornstein S, Han Z, Lu X, Wisell J, Li F, Song J, Lu SL, Jimeno A, Roop DR, Wang XJ. Epithelial stem cell mutations that promote squamous cell carcinoma metastasis. J Clin Invest. 2013 Sep 3. pii: 65856.

Meng W, Ye Z, Cui R, Perry J, Dedousi-Huebner V, Huebner A, Wang Y, Li B, Volinia S, Nakanishi H, Kim T, Suh SS, Ayers LW, Ross P, Croce C, Chakravarti A, Victor J, Lautenschlaeger T. MicroRNA-31 predicts the presence of lymph node metastases and survival in lung adenocarcinoma patients. Clin Cancer Res. 2013 Aug 14. [Epub ahead of print].

Bier A, Giladi N, Kronfeld N, Lee HK, Cazacu S, Finniss S, Xiang C, Poisson L, de Carvalho AC, Slavin S, Jacoby E, Yalon M, Toren A, Mikkelsen T, Brodie C. MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1. Oncotarget. 2013 May;4(5):665-76.

Zhu Y, Wang D, Wang F, Li T, Dong L, Liu H, Ma Y, Jiang F, Yin H, Yan W, Luo M, Tang Z, Zhang G, Wang Q, Zhang J, Zhou J, Yu J. A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Res. 2013 Apr 1;41(7):4129-4143.

Hu S, Wilson KD, Ghosh Z, Han L, Wang Y, Lan F, Ransohoff KJ, Burridge P, Wu JC. MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2. Stem Cells. 2013 Feb;31(2):259-68.

Okuda H, Xing F, Pandey PR, Sharma S, Watabe M, Pai SK, Mo YY, Iiizumi-Gairani M, Hirota S, Liu Y, Wu K, Pochampally R, Watabe K. miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4. Cancer Res. 2013 Feb 15;73(4):1434-44.

Zhang LY, Ho-Fun Lee V, Wong AM, Kwong DL, Zhu YH, Dong SS, Kong KL, Chen J, Tsao SW, Guan XY, Fu L. MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. Carcinogenesis. 2013 Feb;34(2):454-63.

Li Y, Gao L, Luo X, Wang L, Gao X, Wang W, Sun J, Dou L, Li J, Xu C, Wang L, Zhou M, Jiang M, Zhou J, Caligiuri MA, Nervi C, Bloomfield CD, Marcucci G, Yu L. Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway. Blood. 2013 Jan 17;121(3):499-509.

Kong W, He L, Richards EJ, Challa S, Xu CX, Permuth-Wey J, Lancaster JM, Coppola D, Sellers TA, Djeu JY, Cheng JQ. Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer. Oncogene. 2013 Jan 28. doi: 10.1038/onc.2012.636. [Epub ahead of print].

Yang H, Cho ME, Li TW, Peng H, Ko KS, Mato JM, Lu SC. MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma. J Clin Invest. 2013 Jan 2;123(1):285-9.

Motohashi N, Alexander MS, Casar JC, Kunkel LM. Identification of a novel microRNA that regulates the proliferation and differentiation in muscle side population cells. Stem Cells Dev. 2012 Nov 1;21(16):3031-43.

Cheng WC, Kingsbury TJ, Wheelan SJ, Civin CI. A simple high-throughput technology enables gain-of-function screening of human microRNAs. Biotechniques. 2013 Feb;54(2):77-86. (PDF) »

Yin KJ, Olsen K, Hamblin M, Zhang J, Schwendeman SP, Chen YE. Vascular Endothelial Cell-specific MicroRNA-15a Inhibits Angiogenesis in Hindlimb Ischemia. J Biol Chem. 2012 Aug 3;287(32):27055-64.

Yan D, Dong XD, Chen X, Yao S, Wang L, Wang J, Wang C, Hu DN, Qu J, Tu L. Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2s. PLoS One. 2012;7(7):e40967.

Cittelly DM, Finlay-Schultz J, Howe EN, Spoelstra NS, Axlund SD, Hendricks P, Jacobsen BM, Sartorius CA, Richer JK. Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4. Oncogene. 2012 Jul 2. doi: 10.1038/onc.2012.275.

Fayyad-Kazan H, Rouas R, Fayyad-Kazan M, Badran R, El Zein N, Lewalle P, Najar M, Hamade E, Jebbawi F, Merimi M, Romero P, Burny A, Badran B, Martiat P. MicroRNA profile of circulating CD4-positive regulatory T cells in human adults and impact of differentially expressed microRNAs on expression of two genes essential to their function. J Biol Chem. 2012 Mar 23;287(13):9910-22.

Weeraratne SD, Amani V, Teider N, Pierre-Francois J, Winter D, Kye MJ, Sengupta S, Archer T, Remke M, Bai AH, Warren P, Pfister SM, Steen JA, Pomeroy SL, Cho YJ. Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma. Acta Neuropathol. 2012 Apr;123(4):539-52. (PDF) »

Trotta R, Chen L, Ciarlariello D, Josyula S, Mao C, Costinean S, Yu L, Butchar JP, Tridandapani S, Croce CM, Caligiuri MA. miR-155 regulates IFN-y production in natural killer cells. Blood. 2012 Apr 12;119(15):3478-85.

Lars Maegdefessel, Junya Azuma, Ryuji Toh, Denis R. Merk, Alicia Deng, Jocelyn T. Chin, Uwe Raaz, Anke M. Schoelmerich, Azad Raiesdana, Nicholas J. Leeper, Michael V. McConnell, Ronald L. Dalman, Joshua M. Spin, Philip S. Tsao. Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development. J Clin Invest. 2012; 122(2):497. (PDF) »

Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Goedeke L, Liu X, Khatsenko OG, Kaimal V, Lees CJ, Fernandez-Hernando C, Fisher EA, Temel RE, Moore KJ. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature. 2011 Oct 19;478(7369):404-7.

Cichocki F, Felices M, McCullar V, Presnell SR, Al-Attar A, Lutz CT, Miller JS. Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol. 2011 Dec 15;187(12):6171-5. (PDF) »

Leone V, D'Angelo D, Rubio I, de Freitas PM, Federico A, Colamaio M, Pallante P, Medeiros-Neto G, Fusco A. MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha. J Clin Endocrinol Metab. 2011 Sep;96(9):E1388-98. (PDF) »

Fu J-D, Rushing SN, Lieu DK, Chan CW, Kong C-W, et al. Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes. PLoS ONE 6(11): e27417. doi:10.1371/journal.pone.0027417. (PDF) »

Kasar S, Salerno E, Yuan Y, Underbayev C, Vollenweider D, Laurindo MF, Fernandes H, Bonci D, Addario A, Mazzella F, Raveche E. Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia. Genes Immun. 2011 Sep 1. doi: 10.1038/gene.2011.58. [Epub ahead of print].

Turchinovich A, Weiz L, Langheinz A, Burwinkel B. Characterization of extracellular circulating microRNA. Nucleic Acids Res. 2011 Sep 1;39(16):7223-33.

Leone V, D'Angelo D, Rubio I, de Freitas PM, Federico A, Colamaio M, Pallante P, Medeiros-Neto G, Fusco A. MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha. J Clin Endocrinol Metab. 2011 Sep;96(9):E1388-98.

Simone Brabletz, Karolina Bajdak, Simone Meidhof, Ulrike Burk1, Gabriele Niedermann, Elke Firat, Ulrich Wellner, Arno Dimmler, Gerhard Faller, Jorg Schubert and Thomas Brabletz. The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. The EMBO Journal (2011) 30, 770-782. (PDF) »

Imane Azzouzi, Hansjoerg Moest, Jeannine Winkler, Jean-Claude Fauchere, Andre P. Gerber, Bernd Wollscheid, Markus Stoffel, Markus Schmugge, Oliver Speer. MicroRNA-96 Directly Inhibits Gamma-Globin Expression in Human Erythropoiesis. PLoS ONE 6(7): e22838. doi:10.1371/journal.pone.0022838. (PDF) »

Shtutman M, Baig M, Levina E, Hurteau G, Lim CU, Broude E, Nikiforov M, Harkins TT, Carmack CS, Ding Y, Wieland F, Buttyan R, Roninson IB. Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit Zeta-2 renders tumor cells dependent on its paralogous gene COPZ1. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12449-54.

Wang Z, Zhao Y, Smith E, Goodall GJ, Drew PA, Brabletz T, Yang C. Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b. Toxicol Sci. 2011 May;121(1):110-22.

Katey J. Rayner, Yajaira Suárez, Alberto Dávalos, Saj Parathath, Michael L. Fitzgerald, Norimasa Tamehiro, Edward A. Fisher, Kathryn J. Moore, Carlos Fernández-Hernando. miR-33 Contributes to the Regulation of Cholesterol Homeostasis. Science. 2010 Jun 18;328(5985):1570-3.

Shi XB, Xue L, Ma AH, Tepper CG, Kung HJ, White RW. miR-125b promotes growth of prostate cancer xenograft tumor through targeting pro-apoptotic genes. Prostate. 2011 Apr;71(5):538-49.

Hollander JA, Im HI, Amelio AL, Kocerha J, Bali P, Lu Q, Willoughby D, Wahlestedt C, Conkright MD, Kenny PJ. Striatal microRNA controls cocaine intake through CREB signalling. Nature. 2010 Jul 8;466(7303):197-202.

Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM. MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci USA. 2010 Dec 7;107(49):21098-103. (PDF) »

Hassan MQ, Gordon JA, Beloti MM, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB. A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program. Proc Natl Acad Sci U S A. 2010 Oct 27. [Epub ahead of print]. (PDF) »

Heh-In Im, Jonathan A Hollander, Purva Bali and Paul J Kenny. MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Nature Neuroscience. 2010 Aug 15. [Epub ahead of print].

Wilson KD, Hu S, Venkatasubrahmanyam S, Fu JD, Sun N, Abilez OJ, Baugh JJ, Jia F, Ghosh Z, Li RA, Butte AJ, Wu JC. Dynamic MicroRNA Expression Programs during Cardiac Differentiation of Human Embryonic Stem Cells: Role for miR-499. Circ Cardiovasc Genet. 2010 Aug 23. [Epub ahead of print].

Masakazu Kamata, Min Liang, Shirley Liu, Yoshiko Nagaoka and Irvin S. Y. Chen. Live Cell Monitoring of hiPSC Generation and Differentiation Using Differential Expression of Endogenous microRNAs. PLoS One. 2010; 5(7): e11834. (PDF) »

Valeri N, Gasparini P, Fabbri M, Braconi C, Veronese A, Lovat F, Adair B, Vannini I, Fanini F, Bottoni A, Costinean S, Sandhu SK, Nuovo GJ, Alder H, Gafa R, Calore F, Ferracin M, Lanza G, Volinia S, Negrini M, McIlhatton MA, Amadori D, Fishel R, Croce CM. Modulation of mismatch repair and genomic stability by miR-155. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6982-7. (PDF) »

Kotaro Sasaki, Gary Kohanbash, Aki Hoji, Ryo Ueda, Heather A McDonald, Todd A Reinhart, Jeremy Martinson, Michael T Lotze, Francesco M Marincola, Ena Wang, Mitsugu Fujita, Hideho Okada. miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy. Journal of Translational Medicine 2010, 8:17. (PDF) »

Kong W, He L, Coppola M, Guo J, Esposito NN, Coppola D, Cheng JQ. MicroRNA-155 regulates cell survival, growth and chemosensitivity by targeting FOXO3a in breast cancer. J Biol Chem. 2010 Apr 6. [Epub ahead of print]. (PDF) »

Hasan Rajabi,Caining Jin,Rehan Ahmad,Andrew Cain McClary,Maya Datt Joshi and Donald Kufe. Mucin 1 Oncoprotein Expression Is Suppressed by the miR-125b Oncomir. Genes and Cancer Jan 2010, vol. 1 no. 1 62-68. (PDF) »

Gururajan M, Haga CL, Das S, Leu CM, Hodson D, Josson S, Turner M, Cooper MD. MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int Immunol. 2010 May 23. [Epub ahead of print]

Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM. MicroRNA 29b functions in acute myeloid leukemia. Blood. 2009 Dec 17;114(26):5331-41.

Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 2009 Aug 6;460(7256):705-10.

Xiaowei Wang. A PCR-based platform for microRNA expression profiling studies. RNA (2009), 15:716-723. (PDF) »

Li X, Shen Y, Ichikawa H, Antes T, Goldberg GS. Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration. Oncogene. (2009 Sep 21): 1-12. (PDF) »

Ramiro Garzon, Shujun Liu, Muller Fabbri, Zhongfa Liu, Catherine E.A. Heaphy, Elisa Callegari, Sebastian Schwind, Jiuxia Pang, Jianhua Yu, Natarajan Muthusamy, Violaine Havelange, Stefano Volinia, William Blum, Laura J. Rush, Danilo Perrotti, Michael Andreeff, Clara D. Bloomfield, John C. Byrd, Kenneth Chan, Lai-Chu Wu, Carlo M. Croce, and Guido Marcucci. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood, 18 June 2009, Vol. 113, No. 25, pp. 6411-6418.

Dongsheng Yan, Xiang Da (Eric) Dong, Xiaoyan Chen, Lihua Wang, Chunjing Lu, Jiao Wang, Jia Qu, and LiLi Tu. MicroRNA-1/206 Targets c-Met and Inhibits Rhabdomyosarcoma Development. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 284, NO. 43, pp. 29596-29604, October 23, 2009. (PDF) »

Can-Jie Guo, Qin Pan, Bo Jiang, Guang-Yu Chen and Ding-Guo Li. Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells. Apoptosis (2009) 14:1331-1340. (PDF) »

Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, Li Z, Wu Z, Pei G. MicroRNA miR-326 regulates T(H)-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol. 2009 Oct 18. (PDF) »

Qing Ji, Xinbao Hao, Min Zhang, Wenhua Tang, Meng Yang, Ling Li, Debing Xiang, Jeffrey T. DeSano, Guido T. Bommer, Daiming Fan, Eric R. Fearon, Theodore S. Lawrence, Liang Xu. MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells. PLoS ONE 4(8): e6816 (2009).

Manjunatha R. Benakanakere, Qiyan Li, Mehmet A. Eskan, Amar V. Singh, Jiawei Zhao, Johnah C. Galicia, Panagiota Stathopoulou, Thomas B. Knudsen, and Denis F. Kinane. Modulation of TLR2 Protein Expression by miR-105 in Human Oral Keratinocytes. J. Biol. Chem., Vol. 284, Issue 34, 23107-23115, August 21, 2009. (PDF) »

Lu TX, Munitz A, Rothenberg ME. MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol. 2009 Apr 15;182(8):4994-5002. (PDF) »

Yuan-Hau Tsai, Min-Fen Wu, Yu-Hsuan Wu, Shing-Jyh Chang, Su-Fang Lin, Tyson V. Sharp and Hsei-Wei Wang. The M Type K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus Regulates MicroRNA Expression via Its SH2-Binding Motif To Induce Cell Migration and Invasion. Journal of Virology, January 2009, p. 622-632, Vol. 83, No. 2 (PDF) »

Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY. p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc Natl Acad Sci U S A. 2009 Mar 3; 106(9):3207-12. (PDF) »

Z Lu, M Liu, V Stribinskis, CM Klinge, KS Ramos, NH Colburn and Y Li. MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene (2008) 27, 4373-4379. (PDF) »

Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, Raychaudhury A, Newton HB, Chiocca EA, Lawler S. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 2008 Nov 15;68(22):9125-30. (PDF) »

Qing Ji, Xinbao Hao, Yang Meng, Min Zhang, Jeffrey DeSano, Daiming Fan and Liang Xu. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer 2008, 8:266 doi:10.1186/1471-2407-8-266. (PDF) »

Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 2007 Sep 15;67(18):8433-8. (PDF) »

 

MicroRNA Technical References

microRNA discovery

Lee RC, Feinbaum RL, Ambros V. “The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14”. Cell, 75:843-854, 1993.

Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvits HR, Ruvkun G. “The 21-nucleotides let-7 RNA regulates developmental timing in Caenorhabditis elegans”. Nature, 403:901-906, 2000.

Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. “Identification of novel genes coding for small expressed RNAs”. Science, 294:853-858, 2001.

microRNA targets prediction

Rhoades MW, Reinhart BJ, Lim LP, Burge CB, Bartel B, Bartel DP. “Prediction of plant microRNA targets”. Cell, 110:513-520, 2002.

Lewis BP, Burge CB, Bartel DP. “Conserved seed pairing, often flanking by adenosines, indicates that thousands of human genes are microRNA targets”. Cell, 120:15-20, 2005.

John, B., C. Sander and D. S. Marks (2006). "Prediction of human microRNA targets." Methods Mol Biol, 342: 101-13.

Vector-based microRNA expression

Mathijs Voorhoeve, P., C.L. Sage, M. Schrier, A.J.M.Gillis, H. Stoop, R.Nagel, Y. Liu, J.V.Duijse, J. Drost, A. Griekspoor, E. Zlotorynski, N. Yabuta, G. D.Vita, H. Nojima, L.H.J.Looijenga, and R. Agami (2006). “A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors.” Cell, 124, 1169-1181.

Shin, K. J., E. A. Wall, J. R. Zavzavadjian, L. A. Santat, J. Liu, J. I. Hwang, R. Rebres, T. Roach, W. Seaman, M. I. Simon and I. D. Fraser (2006). "A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression." PNAS U S A, 103(37): 13759-64.

Stegmeier, F., G. Hu, R. J. Rickles, G. J. Hannon and S. J. Elledge (2005). "A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells." PNAS U S A, 102(37): 13212-7.

Primary microRNA processing

Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN. “The Drosha-DGCR8 complex in primary microRNA processing”. Gene Develop, 18: 3016-3027, 2004.

Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT, Kim VN. “Molecular basis for the recognision of primary microRNAs by the Drosha-DGCR8 complex”. Cell, 125: 887-901.2006.

Zeng Y, Yi R, Cullen BR. “Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha”. EMBO J, 24:138-148, 2005.

Zeng Y, Cullen BR. “Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences”. J Bio Chem, 280:27595-27603, 2005.

microRNA functional study

Bennasser, Y., S. Y. Le, M. L. Yeung and K. T. Jeang (2004). "HIV-1 encoded candidate micro-RNAs and their cellular targets." Retrovirology, 1(1): 43.

Esau C, Kang X, Peralta E, Hanson E, Marcusson EG, Ravichandran LV, Sun Y, Koo S, Perera RJ, Jain R, Dean NM, Freier SM, Bennett CF, Lollo B, Griffey R. MicroRNA-143 regulates adipocyte differentiation. J Biol Chem. 2004 Dec 10;279(50):52361-5.

Hariharan, M., V. Scaria, B. Pillai and S. K. Brahmachari (2005). "Targets for human encoded microRNAs in HIV genes." Biochem Biophys Res Commun, 337(4): 1214-8.

Johnson, S. M., H. Grosshans, J. Shingara, M. Byrom, R. Jarvis, A. Cheng, E. Labourier, K. L. Reinert, D. Brown and F. J. Slack (2005). "RAS is regulated by the let-7 microRNA family." Cell, 120(5): 635-47.

Kim, V. N. (2005). "Small RNAs: classification, biogenesis, and function." Mol Cells, 19(1): 1-15.

Lee, R. C., R. L. Feinbaum and V. Ambros (1993). "The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14." Cell, 75(5): 843-54.

Lee, Y., K. Jeon, J. T. Lee, S. Kim and V. N. Kim (2002). "MicroRNA maturation: stepwise processing and subcellular localization." Embo J, 21(17): 4663-70.

Olsen, P. H. and V. Ambros (1999). "The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation." Dev Biol, 216(2): 671-80.

Pfeffer, S., M. Zavolan, F. A. Grasser, M. Chien, J. J. Russo, J. Ju, B. John, A. J. Enright, D. Marks, C. Sander and T. Tuschl (2004). "Identification of virus-encoded microRNAs." Science, 304(5671): 734-6.

Yi, R., Y. Qin, I. G. Macara and B. R. Cullen (2003). "Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs." Genes Dev, 17(24): 3011-6.