Profile microRNAs in Cancer
Pre-formatted qPCR array
- Oncogenic markers
- Tumor progressive microRNAs
- Anti-apoptotic microRNAs
Detect microRNAs most commonly found in Cancer
MicroRNAs modulate a variety of cellular pathways, including development, differentiation, cell proliferation, and apoptosis, and dysregulation of microRNA expression underlies specific oncogenic events in human cancer. It has been shown that microRNA signatures can distinguish normal from tumor tissue, cancer type and tissue of origin, and may also correlate with disease outcome. There is a general down-regulation of a number of microRNAs in tumors compared with normal tissues in multiple human cancers. Hierarchical clustering analysis of microRNA expression profiles is able to distinguish tumor from normal pancreas, pancreatitis and cell lines. In brain tissue, 30 microRNAs are differentially expressed between normal pituitary and pituitary adenomas, and among these, the expression profiles of 24 microRNAs serves as a predictive signature of pituitary adenoma. MicroRNA signatures have also been reported in chronic lymphocytic leukemia (CLL), lung cancer, pituitary adenomas, uterine leiomyomas and adult acute myeloid leukemia (AML). Of considerable interest has been the demonstration that microRNA expression profiles successfully classify poorly differentiated tumors. In addition, microRNA expression profiles have been shown to correlate with disease outcome.
Simple workflow with rapid qPCR data results
The OncoMir collection is a pre-formatted set of 94 qPCR assays that enable the simultaneous profiling of the top microRNAs involved in cancer phenotypes. There is only one single cDNA synthesis required and then load the qPCR array to collect the real-time qPCR data for differential expression analysis.