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pPACK Lentivector Packaging Systems

Efficient Viral Production

pPACK™ Lentivector Packaging System

  • Designed to package most 3rd-generation lentivectors into pantropic pseudoviral particles, the FIV and HIV-based pPACK Packaging Systems make it easy to deliver and express lentiviral constructs in a wide-range of mammalian cells.

Online Resources

Product Citations

Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ. Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein. Exp Mol Med. 2013 May 10;45:e22.

Jiang K, Yang Z, Cheng L, Wang S, Ning K, Zhou L, Lin J, Zhong H, Wang L, Li Y, Huang J, Zhang H, Ye Q. Mediator of ERBB2-driven Cell Motility (MEMO) Promotes Extranuclear Estrogen Receptor Signaling Involving the Growth Factor Receptors IGF1R and ERBB2. J Biol Chem. 2013 Aug 23;288(34):24590-9.

Wang G, Chen C, Yang R, Cao X, Lai S, Luo X, Feng Y, Xia X, Gong J, Hu J. p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-kB pathway. Angiogenesis. 2013 Jul;16(3):561-73.

White RA, Neiman JM, Reddi A, Han G, Birlea S, Mitra D, Dionne L, Fernandez P, Murao K, Bian L, Keysar SB, Goldstein NB, Song N, Bornstein S, Han Z, Lu X, Wisell J, Li F, Song J, Lu SL, Jimeno A, Roop DR, Wang XJ. Epithelial stem cell mutations that promote squamous cell carcinoma metastasis. J Clin Invest. 2013 Sep 3. pii: 65856.

Meng W, Ye Z, Cui R, Perry J, Dedousi-Huebner V, Huebner A, Wang Y, Li B, Volinia S, Nakanishi H, Kim T, Suh SS, Ayers LW, Ross P, Croce C, Chakravarti A, Victor J, Lautenschlaeger T. MicroRNA-31 predicts the presence of lymph node metastases and survival in lung adenocarcinoma patients. Clin Cancer Res. 2013 Aug 14. [Epub ahead of print].

Mendenhall A, Lesnik J, Mukherjee C, Antes T, Sengupta R. Packaging HIV- or FIV-based lentivector expression constructs and transduction of VSV-G pseudotyped viral particles. J Vis Exp. 2012 Apr 8;(62):e3171.

Tomlinson JJ, Boudreau A, Wu D, Abdou Salem H, Carrigan A, Gagnon A, Mears AJ, Sorisky A, Atlas E, Haché RJ. Insulin sensitization of human preadipocytes through glucocorticoid hormone induction of forkhead transcription factors. Mol Endocrinol. 2010 Jan;24(1):104-13.

Liu B, Peng XC, Zheng XL, Wang J, Qin YW. MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer. 2009 Feb 13. [Epub ahead of print].

Zhang Q, Huang A, Lin YC, Yu HG. Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes. Biochim Biophys Acta. 2009 Feb 21. (PDF) »

Thal D, Xavier CP, Rosentreter A, Linder S, Friedrichs B, Waha A, Pietsch T, Stumpf M, Noegel A, Clemen C. Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy. J Pathol. 2008 Mar;214(4):415-24. (PDF) »

Li W., Hardwick M., Rpsenthal D., Culty M., and Papadopoulos V. Peripheral-type benzodiazepine receptor overexpression and knockdown in human breast cancer cells indicate its prominent role in tumor cell proliferation. Biochemical Pharmacology 73 (4): 491-503, 2007. (PDF) »

Sarojini H., Medepalli K., Terry D. A., Alphenaar B. W., and Wang E. Localized delivery of DNA to the cells by viral collagen-loaded silica colloidal crystals. BioTechniques® 43(2): Advanced Online Publication, 2007.

Stoner M. A., Auerbach S. S., Zamule S. M., Strom S. C., and Omiecinski C. J. Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites. Nucleic Acids Research 35 (7): 2177-2190, 2007. (PDF) »

Solomon S. Shaftel, Stephanos Kyrkanides, John A. Olschowka, Jen-nie H. Miller, Renee E. Johnson and M. Kerry O—Banion. Sustained hippocampal IL-1— overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J. Clin. Invest., 117:1595-1604, 2007. (PDF) »

Lee J.-J., Chen P. B., Yang S.-H., Cheng C.-H., Chueh L.-L., Pang V. F., Michael Hsiao M., Lin C.-T. Effect of the VP3 gene of chicken anemia virus on canine mammary tumor cell. American Journal of Veterinary Research 68 (4): 411-422, 2007.