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PEG-it™ Virus Concentration

Easily Concentrate Lentiviruses with PEG-it™

PEG-it™ Virus Precipitation Solution

  • Easy to use-no ultracentrifugation
  • Cost-effective
  • Cryoprotects virus, non-toxic to cells

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Li X, Nadauld L, Ootani A, Corney DC, Pai RK, Gevaert O, Cantrell MA, Rack PG, Neal JT, Chan CW, Yeung T, Gong X, Yuan J, Wilhelmy J, Robine S, Attardi LD, Plevritis SK, Hung KE, Chen CZ, Ji HP, Kuo CJ. Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat Med. 2014 Jul;20(7):769-77.

Tan S, Duan H, Xun T, Ci W, Qiu J, Yu F, Zhao X, Wu L, Li L, Lu L, Jiang S, Liu S. HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy. Lab Invest. 2014 Jul;94(7):777-87.

Kaufman MR, Albers RE, Keoni C, Kulkarni-Datar K, Natale DR, Brown TL. Important aspects of placental-specific gene transfer. Theriogenology. 2014 Oct 15;82(7):1043-8.

Poku RA, Amissah F, Duverna R, Aguilar BJ, Kiros GE, Lamango NS. Polyisoprenylated methylated protein methyl esterase as a putative drug target for androgen-insensitive prostate cancer. Ecancermedicalscience. 2014 Aug 28;8:459.

Boehler RM, Kuo R, Shin S, Goodman AG, Pilecki MA, Gower RM, Leonard JN, Shea LD. Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype. Biotechnol Bioeng. 2014 Jun;111(6):1210-21.

Kijima N, Hosen N, Kagawa N, Hashimoto N, Kinoshita M, Oji Y, Sugiyama H, Yoshimine T. Wilms' tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis. Anticancer Res. 2014 Jan;34(1):61-7.

Chen ZJ, Wang WP, Chen YC, Wang JY, Lin WH, Tai LA, Liou GG, Yang CS, Chi YH. Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies. J Cell Sci. 2014 Apr 15;127(Pt 8):1792-804.

Seo JH, Jeong ES, Choi YK. Therapeutic effects of lentivirus-mediated shRNA targeting of cyclin D1 in human gastric cancer. BMC Cancer. 2014 Mar 11;14:175.

Duncan MT, Shin S, Wu JJ, Mays Z, Weng S, Bagheri N, Miller WM, Shea LD. Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocytic and erythroid differentiation. Biotechnol Bioeng. 2014 Oct;111(10):2082-94.

Kao JH, Gao MJ, Yang PP, Law PY, Loh HH, Tao PL. The effect of naltrexone on neuropathic pain in mice locally transfected with the mutant mu-opioid receptor gene in spinal cord. Br J Pharmacol. 2014 May 28. doi: 10.1111/bph.12790.

Anastasia A, Deinhardt K, Wang S1, Martin L, Nichol D, Irmady K, Trinh J, Parada L, Rafii S, Hempstead BL, Kermani P. Trkb signaling in pericytes is required for cardiac microvessel stabilization. PLoS One. 2014 Jan 31;9(1):e87406.

Eisfeld AK, Schwind S, Patel R, Huang X, Santhanam R, Walker CJ, Markowitz J, Hoag KW, Jarvinen TM, Leffel B, Perrotti D, Carson WE 3rd, Marcucci G, Bloomfield CD, de la Chapelle A. Intronic miR-3151 within BAALC drives leukemogenesis by deregulating the TP53 pathway. Sci Signal. 2014 Apr 15;7(321):ra36.

Hartman ME, Librande JR, Medvedev IO, Ahmad RN, Moussavi-Harami F, Gupta PP, Chien WM, Chin MT. An optimized and simplified system of mouse embryonic stem cell cardiac differentiation for the assessment of differentiation modifiers. PLoS One. 2014 Mar 25;9(3):e93033.

Kim N, Kim M, Yun S, Doh J, Greenberg PD, Kim TD, Choi I. MicroRNA-150 regulates the cytotoxicity of natural killers by targeting perforin-1. J Allergy Clin Immunol. 2014 Jul;134(1):195-203.

Matsuoka K, Asano Y, Higo S, Tsukamoto O, Yan Y, Yamazaki S, Matsuzaki T, Kioka H, Kato H, Uno Y, Asakura M, Asanuma H, Minamino T, Aburatani H, Kitakaze M, Komuro I, Takashima S. Noninvasive and quantitative live imaging reveals a potential stress-responsive enhancer in the failing heart. FASEB J. 2014 Apr;28(4):1870-9.

Leyton-Mange JS, Mills RW, Macri VS, Jang MY, Butte FN, Ellinor PT, Milan DJ. Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor. Stem Cell Reports. 2014 Feb 6;2(2):163-70.

Allard J, Li K, Lopez XM, Blanchard S, Barbot P, Rorive S, Decaestecker C, Pochet R, Bohl D, Lepore AC, Salmon I, Nicaise C. Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells. Regen Med. 2014;9(4):437-52.

DeBoer SR, Dolios G, Wang R, Sisodia SS. Differential release of β-amyloid from dendrite- versus axon-targeted APP. J Neurosci. 2014 Sep 10;34(37):12313-27.

Kim J, Zhang Y, Skalski M, Hayes J, Kefas B, Schiff D, Purow B, Parsons S, Lawler S, Abounader R. microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma. Cancer Res. 2014 Mar 1;74(5):1541-53.

Mottola G, Boucherit N, Trouplin V, Oury Barry A, Soubeyran P, Mege JL, Ghigo E. Tropheryma whipplei, the agent of Whipple's disease, affects the early to late phagosome transition and survives in a Rab5- and Rab7-positive compartment. PLoS One. 2014 Feb 24;9(2):e89367.

Gower RM, Boehler RM, Azarin SM, Ricci CF, Leonard JN, Shea LD. Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression. Biomaterials. 2014 Feb;35(6):2024-31.

Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K. Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. PLoS One. 2014 Apr 9;9(4):e94735.

Wang N, Rajasekaran N, Hou T, Mellins ED. Transgene expression in various organs post BM-HSC transplantation. Stem Cell Res. 2014 Jan;12(1):209-21.

Irmady K, Jackman KA, Padow VA, Shahani N, Martin LA, Cerchietti L, Unsicker K, Iadecola C, Hempstead BL. Mir-592 regulates the induction and cell death-promoting activity of p75NTR in neuronal ischemic injury. J Neurosci. 2014 Feb 26;34(9):3419-28.

Chetty S, Friedman AR, Taravosh-Lahn K, Kirby ED, Mirescu C, Guo F, Krupik D, Nicholas A, Geraghty AC, Krishnamurthy A, Tsai MK, Covarrubias D, Wong AT, Francis DD, Sapolsky RM, Palmer TD, Pleasure D, Kaufer D. Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry. 2014 Feb 11. doi: 10.1038/mp.2013.190.

Han H, Xu D, Liu C, Claesson HE, Bj���¶rkholm M, Sjoberg J. Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells. PLoS One. 2014 Jan 20;9(1):e85085.

Kumar D, Shankar S, Srivastava RK. Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. Cancer Lett. 2014 Feb 28;343(2):179-89.

Brix DM, Rafn B, Bundgaard Clemmensen K, Andersen SH, Ambartsumian N, Jaattela M, Kallunki T. Screening and identification of small molecule inhibitors of ErbB2-induced invasion. Mol Oncol. 2014 Jul 12. pii: S1574-7891(14)00159-8.

Fernando J, Malfettone A, Cepeda EB, Vilarrasa-Blasi R, Bertran E, Raimondi G, Fabra A, Alvarez-Barrientos A, Fernandez-Salguero P, Fernandez-Rodr���­guez CM, Giannelli G, Sancho P, Fabregat I. A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells. Int J Cancer. 2014 Jul 23. doi: 10.1002/ijc.29097.

Skartsis N, Martinez L, Camilo Duque J, Tabbara M, Velazquez OC, Asif A, Andreopoulos F, Salman LH, Vazquez-Padron RI. C-KIT SIGNALING DETERMINES NEOINTIMAL HYPERPLASIA IN ARTERIOVENOUS FISTULAE. Am J Physiol Renal Physiol. 2014 Sep 3:ajprenal.00292.2014.

Ray K, Mengistu M, Yu L, Lewis GK, Lakowicz JR, DeVico AL. Antigenic properties of the HIV envelope on virions in solution. J Virol. 2014 Feb;88(3):1795-808.

Secreto F, Manske M, Price-Troska T, Ziesmer S, Hodge LS, Ansell SM, Cerhan JR, Novak AJ. B-cell activating factor-receptor specific activation of tumor necrosis factor receptor associated factor 6 and the phosphatidyl inositol 3-kinase pathway in lymphoma B cells. Leuk Lymphoma. 2014 Aug;55(8):1884-92.

Fan X, Rai A, Kambham N, Sung JF, Singh N, Petitt M, Dhal S, Agrawal R, Sutton RE, Druzin ML, Gambhir SS, Ambati BK, Cross JC, Nayak NR. Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications. J Clin Invest. 2014 Oct 20. pii: 76864.

Cohen EB, Jun SJ, Bears Z, Barrera FN, Alonso M, Engelman DM, DiMaio D. Mapping the homodimer interface of an optimized, artificial, transmembrane protein activator of the human erythropoietin receptor. PLoS One. 2014 Apr 30;9(4):e95593.

Zhou D, Wang Y, Tokunaga K, Huang F, Sun B, Yang R. The HIV-1 accessory protein Vpr induces the degradation of the anti-HIV-1 agent APOBEC3G through a VprBP-mediated proteasomal pathway. Virus Res. 2014 Sep 6. pii: S0168-1702(14)00349-9.

Iida K, Fukushi J, Matsumoto Y, Oda Y, Takahashi Y, Fujiwara T, Fujiwara-Okada Y, Hatano M, Nabashima A, Kamura S, Iwamoto Y. miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor. Cancer Cell Int. 2013 Mar 4;13(1):21.

Li Y, Moretto-Zita M, Leon-Garcia S, Parast MM. p63 Inhibits Extravillous Trophoblast Migration and Maintains Cells in a Cytotrophoblast Stem Cell-Like State. Am J Pathol. 2014 Oct 7. pii: S0002-9440(14)00491-X.

Wang N, Rajasekaran N, Hou T, Lisowski L, Mellins ED. Comparison of transduction efficiency among various lentiviruses containing GFP reporter in bone marrow hematopoietic stem cell transplantation. Exp Hematol. 2013 Nov;41(11):934-43.

Shimasaki N, Campana D. Natural killer cell reprogramming with chimeric immune receptors. Methods Mol Biol. 2013;969:203-20.

Pelucchi P, Tria V, Martino V, Sabour D, Bertalot G, Molgora S, Palizban M, Gotte M, Zucchi I, Reinbold RA. A Versatile Tool for Stable Inhibition of microRNA Activity. Biology (Basel). 2013 Jun 28;2(3):861-71.

Boehler RM, Shin S, Fast AG, Gower RM, Shea LD. A PLG/HAp composite scaffold for lentivirus delivery. Biomaterials. 2013 Jul;34(21):5431-8.

Meng W, Ye Z, Cui R, Perry J, Dedousi-Huebner V, Huebner A, Wang Y, Li B, Volinia S, Nakanishi H, Kim T, Suh SS, Ayers LW, Ross P, Croce C, Chakravarti A, Victor J, Lautenschlaeger T. MicroRNA-31 predicts the presence of lymph node metastases and survival in lung adenocarcinoma patients. Clin Cancer Res. 2013 Aug 14. [Epub ahead of print].

Mendenhall A, Lesnik J, Mukherjee C, Antes T, Sengupta R. Packaging HIV- or FIV-based lentivector expression constructs and transduction of VSV-G pseudotyped viral particles. J Vis Exp. 2012 Apr 8;(62):e3171.

Singh BN, Fu J, Srivastava RK, Shankar S. Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular Mechanisms. PLoS One. 2011;6(11):e27306. (PDF) »

Huang P, Kishida S, Cao D, Murakami-Tonami Y, Mu P, Nakaguro M, Koide N, Takeuchi I, Onishi A, Kadomatsu K. The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Cancer Res. 2011 Apr 15;71(8):2938-48.

Chen J, Zhang B, Wong N, Lo AW, To KF, Chan AW, Ng MH, Ho CY, Cheng SH, Lai PB, Yu J, Ng HK, Ling MT, Huang AL, Cai XF, Ko BC. Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. Cancer Res. 2011 Jun 15;71(12):4138-49.

Seungjin Shin and Lonnie D. Shea. Lentivirus Immobilization to Nanoparticles for Enhanced and Localized Delivery From Hydrogels. Molecular Therapy (2010) 18 4, 700—706. (PDF) »

Stefano Bartesaghi, Joanne Betts-Henderson, Kelvin Cain, David Dinsdale, Xiaoshan Zhou, Anna Karlsson, Paolo Salomoni1 and Pierluigi Nicotera. Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration. Hum Mol Genet. 2010 May 1;19(9):1669-77. (PDF) »

Seungjin Shin, Hannah M. Tuinstra, David M. Salvay and Lonnie D. Shea. Phosphatidylserine immobilization of lentivirus for localized gene transfer. Biomaterials Volume 31, Issue 15, May 2010, Pages 4353-4359.

Yonghui Zhang, Xiaojing Lin, Guoqin Wang, Jianfang Zhou, Jian Lu, Honglan Zhao, Fengwei Zhang, Jia Wu, Chunqiong Xu, Ning Du, Zi Li, Ye Zhang, Xiaoyi Wang, Shengli Bi, Yuelong Shu, Hongning Zhou, Wenjie Tan, Xiaobing Wu, Zhihui Chen, Yue Wang. Neuraminidase and Hemagglutinin Matching Patterns of a Highly Pathogenic Avian and Two Pandemic H1N1 Influenza A Viruses. PLoS One. 2010; 5(2): e9167. (PDF) »

Ning Sun, Nicholas J. Panetta, Deepak M. Gupta, Kitchener D. Wilson, Andrew Lee, Fangjun Jia, Shijun Hu, Athena M. Cherry, Robert C. Robbins, Michael T. Longaker, and Joseph C. Wu. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A. 2009 September 15; 106(37): 15720—15725. (PDF) »

Pintchovski SA, Peebles CL, Kim HJ, Verdin E, Finkbeiner S. The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons. J Neurosci. 2009 Feb 4;29(5):1525-37. (PDF) »

Zhang Q, Huang A, Lin YC, Yu HG. Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes. Biochim Biophys Acta. 2009 Feb 21. (PDF) »

Badri KR, Zhou Y, Dhru U, Aramgam S, Schuger L. Effects of the SANT domain of tension-induced/inhibited proteins (TIPs), novel partners of the histone acetyltransferase p300, on p300 activity and TIP-6-induced adipogenesis. Mol Cell Biol. 2008 Oct;28(20):6358-72. (PDF) »