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Enhanced Episomal Vectors (EEV)

Persistent, non-integrating transgene expression

High levels of expression

  • Easy to clone formats
  • No special plasmid production
  • Nonviral, non-integrating technology
  • Constitutive and inducible vector formats

Enhanced Episomal Vectors (EEV)

Sustained, non-integrating transgene expression
Avoid the challenges of viral transduction systems with the new EEV nonviral, non-integrating plasmid-based expression vector system. The technology is based on the Epstein-Barr Nuclear Antigen-1 (oriP-EBNA1) that has the ability to replicate in synchrony with the host genome by attaching to the host chromatin and replicating with each cell cycle division. This results in an extended presence within a host cell without integration or modification of the host's genome. SBI has developed an enhanced version of the oriP-EBNA1 technology called the Enhanced Episomal Vector (EEV) platform. The major distinguishing feature of the EEV system from viral or other plasmid-based approaches is its capability to create long-term expressing cell lines without any risk of genomic integration or alterations. This new technology enables sustained transgene expression for several months in both in vitro and in vivo applications.

SBI has developed an enhanced version of the oriP-EBNA1 technology called the Enhanced Episomal Vector (EEV) platform. This new technology enables sustained transgene expression for several months in both in vitro and in vivo applications. There are EEV cloning vectors for constitutive and cumate-inducible formats available as well as pre-made EEV reporters.

EEV Cloning and Expression Vectors

EEV cloning vectors