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CRISPR/Cas9 SmartNucleases™

High efficiency, RNA-guided
genome editing

CRISPR/Cas9 Technologies

  • All-in-one Cas9/gRNA plasmids
  • Injection-ready Cas9 mRNA
  • Packaged Cas9 lentivirus
  • Multiplex gRNA cloning kits
  • Expert technical support

CRISPR/Cas9 SmartNuclease Systems

Genome Editing using guide RNAs

The recent discovery of the CRISPR/Cas9 complex has provided researchers an invaluable tool to target and modify any genomic sequence with high levels of efficacy and specificity. The system, consisting of an RNA-guided nuclease (Cas9) and guide RNA (gRNA) complementary to a target sequence, allows for sequence-specific cleavage of target loci across the genome.

Cas9 SmartNuclease All-in-one Plasmids

Wild-type and mutant CRISPR/Cas9 plasmids

Multiplex gRNA Cloning Kits

Create CRISPR/Cas9 constructs with multiple gRNAs simultaneously for more precise genome editing

Transfection and Injection-ready Cas9 mRNA and gRNA Synthesis Kit

Ready-to-use synthetic Cas9 mRNA for in vivo applications

Cas9 Lentiviral Vectors and Pre-made Virus

Transduce primary cells and make stable Cas9 editing cell lines

Cas9 Detection Systems

Cas9 Antibody and RT-PCR Primer Set Kits


Genome engineering has never been easier.

And yet, important questions remain for scientists wishing to take advantage of this technology in their research:
• How do you make CRISPR/Cas9 technology work for your research?

• With a number of available options for CRISPR/Cas9 reagents, which ones should you use?

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SBI's PrecisionX™ Cas9 SmartNuclease™ system offers proven technology with unparalleled support and expertise to make your use of CRISPR/Cas9 easy and successful from the start.

SBI provides:

  • Detailed Application Notes for Gene Knock-Out, Editing, and Tagging applications;
  • Custom gRNA and HR Donor Vector Design Services
  • Custom Genome Engineering Cloning & Cell Line Services
  • Complimentary Phone Consultation with our Cas9 Experts with every purchase
  • Live Technical Support
  • 3rd-party Validation of In Vitro and In Vivo Applications Using SmartNuclease Reagents


Application Notes:
SBI's genome engineering specialists have created detailed protocols for first-time and experienced users of the CRISPR/Cas9 system, including details on gRNA and HR Targeting Vector design for the following applications:

Custom Design Services:
Take advantage of SBI's design expertise in genome engineering applications with our custom design services to have SBI design the optimal gRNA and/or HR Targeting vector sequences for your project.

Custom Cloning & Cell Line Services:
SBI also offers custom gRNA and HR donor vector cloning and cell line engineering services as a comprehensive solution for any genome engineering project. More details are here.

Third-Party Validation

SBI was the first commercial company to offer CRISPR/Cas9 research tools, starting in April 2013, which means that many researchers have now produced successful results using SBI reagents in their labs. SBI's Cas9 SmartNuclease™ reagents have been used successfully in both in vitro and in vivo applications, with product citations pending publication.

For example, up to a 75% mutation rate was recently achieved at the NIH using SBI's Cas9 SmartNuclease system for direct genome editing in mouse zygotes, with 90% homozygous mutations (both alleles).


Live Technical Support:
Unlike with plasmid repositories, SBI offers live phone support from experienced genome engineering specialists who can guide you through the use of CRISPR/Cas9 reagents and answer any questions you may have.

Free Phone Consultation:
SBI also offers a free phone consultation with the purchase of any Cas9 SmartNuclease reagent to discuss strategies and recommended protocols for your genome engineering application of choice.