Transdifferentiation methods

Two classes of factors have been demonstrated to have the ability to cooperate in intricate regulatory circuits either to generate induced pluripotent stem cells (iPSC) or to convert one specific tissue-type of cells into another: Transcription factors and microRNAs.

Example routes to switch cell lineages

Using either transcription factors, microRNAs, or a combination of these expression vectors can enable cell lineage reprogramming through the following validated routes.