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iPSC Reprogramming Factors

For induction of pluripotent stem cells

Study pluripotency

  • Oct4
  • Nanog and Sox2
  • KLF4 or Lin28
  • c-Myc

Online Resources

 

Technical References

Jia F, Wilson KD, Sun N, Gupta DM, Huang M, Li Z, Panetta NJ, Chen ZY, Robbins RC, Kay MA, Longaker MT, Wu JC. A nonviral minicircle vector for deriving human iPS cells. Nature Methods. 2010 Mar;7(3):197-9.

Rossant, J. 2007. Stem cells: The magic brew. Nature 448, 260–262.

Takahashi, K. and Yamanaka, S. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663–676.

Takahashi K. et al. 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 131: 861–72.

Park, IH et al. 2008. Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 451:141–6.

Baker, Monya 2007. Adult cells reprogrammed to pluripotency, without tumors. Nature Reports Stem Cells. 2007–12–11. 

Nakagawa, M et al. 2008. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nature Biotechnology. 26: 101–106.

Okita, K, et al. 2007. Generation of germline-competent induced pluripotent stem cells. Nature. 448:313–7

Yu, J. et al. 2007. Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science 318: 1917–1920.