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Human Genome-wide

Pooled lentivirus RNAi screens

Identify new targets in any pathway

  • Screen
  • Dissect
  • Discover

Online Resources

Product Citations

Kim YW, Liu TJ, Koul D, Tiao N, Feroze AH, Wang J, Powis G, Yung WK. Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM. Neuro Oncol. 2011 Apr;13(4):367-75.

Wang WH, Studach LL, Andrisani OM. Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication. Hepatology. 2011 Apr;53(4):1137-47. (PDF) »

Malbec M, Pham QT, Plourde MB, Létourneau-Hogan A, Nepveu-Traversy ME, Berthoux L. Murine double minute 2 as a modulator of retroviral restrictions mediated by TRIM5alpha. Virology. 2010 Jul 7. [Epub ahead of print]. (PDF) »

Tsujii H, Eguchi Y, Chenchik A, Mizutani T, Yamada K, Tsujimoto Y. Screening of Cell Death Genes With a Mammalian Genome-wide RNAi Library. J Biochem. 2010 Apr 26. [Epub ahead of print].

Gumireddy K, Li A, Gimotty PA, Klein-Szanto AJ, Showe LC, Katsaros D, Coukos G, Zhang L, Huang Q. KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol. 2009 Oct 4. [Epub ahead of print]. (PDF) »

Xu M, Takanashi M, Oikawa K, Tanaka M, Nishi H, Isaka K, Kudo M, Kuroda M. USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis. Biochem Biophys Res Commun. 2009 Oct 16;388(2):366-71. (PDF) »

Chen Y, Cairns R, Papandreou I, Koong A, Denko NC. Oxygen consumption can regulate the growth of tumors, a new perspective on the warburg effect. PLoS One. 2009 Sep 15;4(9):e7033. (PDF) »

Yeung ML, Houzet L, Yedavalli VS, Jeang KT. A genome-wide short hairpin RNA (shRNA) screening of Jurkat T-cells for human proteins contributory to productive HIV-1 replication. J Biol Chem. 2009 May 20. [Epub ahead of print]. (PDF) »

Ossovskaya VS, Dolganov G, Basbaum AI. Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth. J Neurosci Methods. 2009 Mar 15;177(2):322-33. (PDF) »

Huang X, Wang JY, Lu X. Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion. BMC Syst Biol. 2008 Jun 13;2:49. (PDF) »

Hwang GW, Hayashi T, Kita K, Takahashi T, Kuge S, Naganuma A. siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells. J Toxicol Sci. 2007 Dec;32(5):581-3. (PDF) »

Hattori H, Zhang X, Jia Y, Subramanian KK, Jo H, Loison F, Newburger PE,Luo HR. RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood, 110 (2): 640-650, 2007 (PDF) »

Useful References for RNAi Screens

How to use shRNA libraries for genetic screening

Nature. 2004 Mar 25;428(6981):427-31

Nature. 2004 Mar 25;428(6981):431-7

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):135-40

Nature 2006 (PDF) »

shRNA Library Review