Reporter Cell Lines
Study modulators of pathway activation
using stable reporter cell lines
Dual reporter systems: GFP & Luciferase
- Stably integrated reporter constructs
- Properly chromatinized transciption responses
- Low background, bright GFP signals
- Quantitate transactivation using Luciferase
Online Resources
Product Citations
Vince JE, Chau D, Callus B, Wong WW, Hawkins CJ, Schneider P, McKinlay M, Benetatos CA, Condon SM, Chunduru SK, Yeoh G, Brink R, Vaux DL, Silke J. TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol. 2008 Jul 14;182(1):171-84. (PDF) »
Technical References
Egan, L. J. and Toruner, M. NF-κB Signaling: Pros and Cons of Altering NF-κB as a Therapeutic Approach. 2006; Ann. N.Y. Acad. Sci. 1072: 114–122.