• Lentiviral technologies
• Stem Cell tools
• MicroRNA research
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System Biosciences continues to create new and unique products as well as improve our well-established product lines. Our commitment to providing leading-edge technologies is matched by our high quality of manufacturing and quality control for all of our research reagents and research project services.
What to be looking for in 2010:
Here is a glimpse of new products on the near horizon.
New Cold Fusion Cloning Kit: Efficient method to rapidly fuse DNA fragments for easy clone construction.
Pluripotency Response Reporters: Track Pluripotency in Living Cells with GFP and Quantitate Activities of Oct4 or Sox2 with Luciferase - all built into the Dual pGreenFire Response Reporters.
miR-Selection System: Novel cellular method to detect microRNA binding to its target mRNA using a lentivector dual reporter system featuring Luciferase (Fire) and a Cytotoxic Sensor (Ctx).
PureFection Transfection reagent: A powerful, broadly applicable transfection reagent for effective and reproducible transfections based on nanotechnology.
Sterol response pGreenFire™ lenti-reporters: Lentivector-based transcription reporters for the monitoring of transcriptional network activity associated with sterol-sensing transcription factors - key to cardiovascular disease pathways.
ExoQuick™ Exosome Precipitation Solution: Isolate Circulating Exosomes in serum and bio-fluids to discover MicroRNA Biomarkers.
New and unique products for 2007–2009
miRZips™: Novel lentivector-based technologies to permanently knockdown MicroRNAs.
iPS Cell Lines: Human and Mouse induced pluripotent matched source and iPS cell lines.
MicroRNA cluster constructs: Study Stem Cell and Cancer microRNA clusters through overexpression.
Dual marker shRNA expression vector: SBI has built a powerful shRNA expression lentivector pGreenPuro™ to enable both GFP and Puro marker selection of stably transduced cells for your RNAi experiments.
LentiStarter™Kit: ptimized set of lentivector reagents for packaging and transduction testing.
miR and PIWI-SNaREs: MicroRNA and piRNA Small Non-coding RNA Enrichment Systems that
use epitope-tagged microRNA processing factors to pull-down the proteins and their associated RNAs. Identify messenger RNAs driven to RISC complexes.
GeneNet™ Focused shRNA Libraries: These focused shRNA Libraries encode a pooled set of shRNAs designed against all genes of a speciic function or class for Human Kinases, Phosphatases or Apoptosis-related genes. These libraries enable targeted high-throughput RNAi screens.
miRNome MicroRNA Profilers: The qPCR arrays include microRNA assays in pre-formatted plates for either the full compliment of human or the full compliment of mouse individual microRNAs with three endogenous reference RNA controls on each plate. All microRNA assays based on the Sanger miRBase microRNA database registered entries.
Lenti-miR™ MicroRNA Precursor Clones: Expanded microRNA precursor collection available in HIV-based Lentiviral Vectors. Over 580 individual microRNA precursor clones available arrayed or as pooled lentivirus for HT screens.
Lentiviral-based Stem Cell Reporters: SBI’s growing list of lentivectors has been developed as the most effective way to deliver genetic constructs into virtually any cell types in vitro and in vivo. SBI has expanded our lentivector construct line into stem cell reporters. Create transgenic cell lines easily to monitor cellular differentiation using cell and pathway-specific promoters linked to GFP reporters.
QuantiMir™ RT Kit: this new and popular technology allows for the real-time qPCR quantitation of hundreds of microRNAs simultaneously from a single cDNA synthesis. Design your own microRNA assays for innovative experimentation.
Cancer microRNA qPCR assay panel (The OncoMir Collection): preformatted microRNA assay panel to assess 95 microRNAs known to be involved in Cancer.
Stem Cell microRNA assay panel: profile 95 microRNAs involved in Stem Cell differentiation enabling the simultaneous monitoring of stem cell self-maintenance, hematopoiesis pathways and neural differentiation.
SBI’s well-established product lines
Full Spectrum™ Complete messenger RNA Amplification Kit: utilize mRNA specific primers targeting the most common motifs in mRNA to provide unbiased, complete representation of entire mRNA transcripts (both the 5’ and 3’ ends).
GeneNet™ siRNA Libraries: Genome-wide, ready-to-use, pre-packaged lentiviral libraries provide an exciting opportunity for the screening of gene functions associated with biological responses.
Interferon Response Detection Kit: distinguish between real RNA interference and stress-related cellular responses.
PathNet™ Transcriptional Reporter Lentivectors: a unique method to create a wide range of stable reporter cell lines for the study of signaling pathways.
We are grateful for your support in the past and look forward to providing you with the best new reagents, technologies and services to accelerate your successful research objectives.
